Juvenile pilocytic astrocytomas: A search for prognostic markers

N Osman - 2022 - open.uct.ac.za
… The cerebellar pilocytic astrocytomas classically show a cyst … described is a duplication at
chromosome 7q34 whereby the … as specific in confirming a diagnosis of pilocytic astrocytoma

Circumscribed astrocytic gliomas

C Hawkins, G Reifenberger, A Perry - Greenfield's Neuropathology 10e … - taylorfrancis.com
… of cysts, a hallmark present in more than 80 per cent of cerebellar … More specific is the
presence of αB-crystallin.… copy number gain of the BRAF gene on 7q34 in a large proportion of …

ATRX protein loss and deregulation of PI3K/AKT pathway is frequent in pilocytic astrocytoma with anaplastic features

A Olar, D Tran, VP Mehta, A Reinhardt… - Clinical …, 2019 - search.proquest.com
… The pyrosequencing primer used for amplifying BRAF at 7q34 … 3) showed BRAF fusion/duplication
by pyrosequencing; 1 of … astrocytomas and a hallmark of cerebellar and optic pathway …

The involvement of the MAPK pathway in pilocytic astrocytomas

D Salles, SF Santino, DA Ribeiro… - … -Research and Practice, 2022 - Elsevier
… of cortical neurogenesis, and midbrain and cerebellum development. Alterations in this
pathway … This duplication at 7q34 is practically specific for pilocytic astrocytomas as it is rare or …

Genetic and histopathological associations with outcome in pediatric pilocytic astrocytoma

SJ Cler, A Skidmore, AT Yahanda, K Mackey… - Journal of …, 2022 - thejns.org
astrocytomas (PAs), the most common CNS tumor in children, 1 are most commonly located
in the cerebellumCerebellar PAs are associated with a higher rate of gross-total resection (…

Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis

N Manoharan, P Ajuyah, A Senapati, M Wong… - Acta Neuropathologica …, 2021 - Springer
… A radiological hallmark of this disease is widespread … , Sylvian fissures, brainstem and
cerebellar folia. Discrete parenchymal … loss and 7q34 gain associated with both classes, but more …

Adult pilocytic astrocytoma in the molecular era: a comprehensive review

TA Gregory, LB Chumbley, JW Henson… - CNS oncology, 2021 - Taylor & Francis
… This is distinct from pediatric PA where cerebellar and cerebral/lobar … duplication of
chromosome 7q34 was reported as a frequent chromosomal abnormality in PA. The 7q34

[HTML][HTML] Pathological perspectives in pilocytic astrocytomas: Extent of resection as the sole critical factor for recurrence-free survival, and the challenge of evaluating …

I Kulac, I Yenidogan, BO Sozmen, A Baygul… - Free …, 2023 - ncbi.nlm.nih.gov
… PA is most commonly located in the posterior fossa, specifically in cerebellar hemispheres.
… The most common genetic alteration is the BRAF internal tandem duplication resulting with a …

Targeted molecular characterization of adult midline and circumscribed gliomas for the identification of new potential targets for personalized therapy

E Trisolini - 2020 - iris.uniupo.it
… The biphasic pattern is best seen in cerebellar tumours. … an approximately 2 Mb duplication
of 7q34, encompassing the … with a histological hallmark of a specific glioneuronal element …

Copy number assessment in the genomic analysis of CNS neoplasia: an evidence-based review from the cancer genomics consortium (CGC) working group on …

SG Neill, J Hauenstein, MM Li, YJ Liu, M Luo, DF Saxe… - Cancer Genetics, 2020 - Elsevier
… for these diagnostically relevant hallmark genomic changes. … in the cerebellum and represent
the most common glioma … majority show a tandem duplication at 7q34 involving gain of …