Evaluation of analgesic and anti-inflammatory activity of purine-2, 6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity

M Zygmunt, M Ślusarczyk, A Jankowska… - Pharmacological …, 2022 - Springer
… cold plate tests, and in the carrageenan-induced edema model… most potent antinociceptive
activity in the formalin test was … in the inflammatory processes is a delayed effect that occurs …

Antinociceptive effect of the hydroethanolic leaf extract of Calotropis procera (Ait) R. Br.(Apocynaceae): Possible involvement of glutamatergic, cytokines, opioidergic …

E Obese, RP Biney, IT Henneh, D Anokwah… - Journal of …, 2021 - Elsevier
… effects exhibited by CPE (100 mg/kg) in the formalin test was … to that of non-selective NSAIDs,
with a reduced risk of certain … effect, as demonstrated by the protracted delay in response …

[HTML][HTML] Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs

V Fattori, TH Zaninelli, FS Rasquel-Oliveira… - Pharmacological …, 2020 - Elsevier
… for example, the use of morphine is related to a delay in NF-κB-… , and LXB 4 reduce edema
and thermal hyperalgesia induced … reduces the second phase of formalin-induced overt pain-…

[HTML][HTML] Chemical composition, antioxidant, anti-inflammatory and antinociceptive activities of the ethanol extract of ripe fruits of Solanum lycocarpum St. Hil …

MG Morais, AA Saldanha, JPC Rodrigues… - Journal of …, 2020 - Elsevier
Pain involves mechanisms related to the response of the … effect observed in the first phase
of the formalin test. … potential, provoking the reduction of ear edema induced by chroton oil and …

Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models

AM Ajayi, CB Ola, MB Ezeagu, PA Adeleke… - Journal of …, 2023 - Elsevier
No noticeable sign of acute toxicity or delayed toxicity was … Naloxone did not significantly
reverse the antinociceptive … The oedema reduction is comparable to those obtained from the …

[PDF][PDF] Antinociceptive and antiinflammatory studies on Tradescantia zebrina

N Baghalpour, SA Ayatollahi, N Naderi… - Pak. J. Bot, 2021 - pakbs.org
… compromise the immune system, cause infections, and delay the diagnosis and treatment of
… of the formalin test.Based on our results from the carrageenan-induced paw edema test, the …

[HTML][HTML] Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel

J Shah, AB Nair, H Shah, S Jacob, TM Shehata… - Asian Journal of …, 2020 - Elsevier
reduction of induced twitches (P < 0.005) in mice and edema … subcutaneous injection (0.1
ml) of formaldehyde (4%) at the left … delayed T max (4 h) in the transdermal therapy of F4 may

Discovery of RC-752, a Novel Sigma-1 receptor antagonist with antinociceptive activity: a promising tool for fighting neuropathic pain

G Rossino, A Marra, R Listro, M Peviani, E Poggio… - Pharmaceuticals, 2023 - mdpi.com
… the swim bladder was not well inflated, and oedema was evident. … related to a potentially
recoverable developmental delay or … The formalin test was chosen as a tonic pain model for the …

[PDF][PDF] Anti-inflammatory effects of propoxazepam on different models of inflammation

NY Golovenko, TA Kabanova… - … of Medicine and …, 2019 - ojs.tdmu.edu.ua
… proved to reduce the volume of acute inflam matory paw edema in … However, formalin test is
sensitive to non-steroidal … antinociceptive effect while at a higher dose (10 mg/kg) had nearly …

Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea

…, RG Thomé, HB Dos Santos, DO Lopes… - …, 2021 - Springer
… Moreover, the in vivo antinociceptive effect was assayed using the formalin test and …
Treatment with the EFDf also resulted in significant paw oedema reduction in the … Full size image …