Repeated oral ketamine for out-patient treatment of resistant depression: randomised, double-blind, placebo-controlled, proof-of-concept study

Y Domany, M Bleich-Cohen, R Tarrasch… - The British Journal of …, 2019 - cambridge.org
… to documented therapeutic trials of at least two antidepressants of … to clinical practice without
larger, randomised studies. Such … major depression. Arch Gen Psychiatry 2006; 63: 856–64. …

Transcranial direct current stimulation for treatment-resistant major depression: A double-blind randomized sham-controlled trial

E Sharafi, A Taghva, M Arbabi… - Clinical EEG and …, 2019 - journals.sagepub.com
… of change during the study P < .… study was not a controlled, randomized trial and the
medications were stable for 3 to 4 weeks; therefore, it was possible that the delayed antidepressant

The efficacy and safety of esketamine in the treatment of major depressive disorder with suicidal ideation: study protocol for a randomized controlled trial

H Liu, X Lan, C Wang, F Zhang, L Fu, W Li, Y Ye, Z Hu… - BMC psychiatry, 2022 - Springer
… Despite this, current conventional antidepressant treatment faces … has a medical emergency
or a change in the patient’s … the study protocol of a randomized double-blind controlled trial

Nutraceuticals for major depressive disorder-more is not merrier: An 8-week double-blind, randomised, controlled trial

J Sarris, GJ Byrne, C Stough, C Bousman… - Journal of affective …, 2019 - Elsevier
… The primary outcome was change in MADRS score. Hypothesis-… existing data for the
antidepressant effect of individual … There was a greater frequency of early termination secondary to …

… of ansofaxine (LY03005) extended-release tablet for major depressive disorder: a randomized, double-blind, placebo-controlled, dose-finding, phase 2 clinical trial

W Mi, F Yang, H Li, X Xu, L Li, Q Tan… - International Journal …, 2022 - academic.oup.com
… was also the first day of the double-blind treatment period and … The primary efficacy endpoint
was the change in HAMD 17 … ER tablets were similar to these SSRIs and better than other …

Stanford neuromodulation therapy (SNT): a double-blind randomized controlled trial

EJ Cole, AL Phillips, BS Bentzley… - American Journal of …, 2022 - Am Psychiatric Assoc
… In the present study, we investigated the antidepressant … the change in depression severity,
as indicated by percent … all clinical trials for major depressive disorder, our study relied on …

… to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial

C Otte, WR Chae, J Nowacki, M Kaczmarczyk… - BMJ open, 2020 - bmjopen.bmj.com
… -on simvastatin to standard antidepressant medication with … secondary outcome variables
change scores in patients’ self-… patients: a double-blind, placebo-controlled, randomized trial. …

… A mol a N d Tramadol Hydrochloride Oral Fix E d Dose Combination on Moderate to Severe Acute Pain in Patients with Acute Low Back Pain—Rationale and Design

G Varrassi, M Hanna, S Coaccioli, M Suada, S Perrot - Pain and Therapy, 2022 - Springer
… compared to placebo at a regular or as-needed dosing … selective serotonin reuptake inhibitors
(SSRIs) and serotonin and … , with 51 switching to TRAM/DKP 75/25 mg and 51 switching to …

Randomized trial of ketamine masked by surgical anesthesia in patients with depression

TR Lii, AE Smith, JR Flohr, RL Okada… - Nature Mental …, 2023 - nature.com
… of adults with moderate-to-severe levels of MDD. A supportive … reaction to ketamine is
needed for an antidepressant response. … in MADRS change scores observed in our study is also …

… therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial

MA Nettis, G Lombardo, C Hastings… - …, 2021 - nature.com
… of antidepressant augmentation with minocycline in patients with … randomised trials (RCTs)
have assessed the augmentation therapy with minocycline 200 mg/day in MDD: one study