… first antidepressant study of its kind, SUSTAIN-1 was a phase 3, multicenter, double-blind,
randomized withdrawal study, … and switched to placebo nasal spray, with oral antidepressant …

… This phase III, double-blind, randomized trial (APOLLO-2 [… time to first perceptible and first
meaningful pain relief is … and meaningful pain relief, and the time to a 1-point change in NRS …

… inflammatory mechanisms in MDD is an important first step in … with moderate MDD currently
receiving antidepressant medication. … The primary outcome for this trial is change in MADRS …

… We defined the primary outcome as the mean change in the … study by Omranifard et al. did
not support the antidepressant … First, most of our included studies only assessed the acute …

… or changing synaptic plasticity via the NMDA receptor complex. Esmethadone … double-blind
trial of patients with MDD who had not responded to between one and three antidepressants …

… correlation between ALCAM and the change of PHQ-9 score (… often found among patients
with major depressive disorder [16… with CAD, The use of antidepressants is often the first line of …

… received an antidepressant in the previous month. As a result, 60 … t-test comparing the score
change from baseline to each time … Earlier animal studies provided prospects for this clinical …

… Assuming a mean difference (MD) of 2.5 between groups … same antidepressant efficacy as
receiving fluoxetine in patients with … First, follow-up duration in the current study was 6 weeks, …

… was a double-blind, placebo-controlled, randomized study to … a transient change in mood
in patients with MDD conceivably … retention of antidepressant effects in the current study could …

… First-line treatments for MDD present significant caveats, as antidepressant medications
are … We will use 4 measurements (continuous linear change from baseline, weeks 2, 4 and …