异位促肾上腺皮质激素# adrenocorticotropic hormone $ ACTH% 综合征# ectopic ACTH
syndrome $ EAS% 作为库欣综合征的> 种特殊类型 $ 是因垂体以外 ACTH
的肿瘤组织分泌过量具有生物活性的 ACTH $ 刺激肾上腺皮质增生并产生过量皮质类固醇引起
的临床综合征 $ 占库欣综合征患者总数的 5% 10%[1] & 国外文献报道最多见病因为肺部或
支气管肿瘤 $ 约占 50% $ 其次分别为胸腺及胰腺肿瘤 $ 各约占 10% $ 还可有甲状腺髓样癌#
medullary thy roid carcinoma $ MTC% $ 嗜铬细胞瘤 $ 胃肠道及生殖系统'前列腺等部位的肿瘤 …

Olfactory neuroblastomas rarely secrete adrenocorticotropic hormone, leading to ectopic
adrenocorticotropic hormone syndrome. However, the prevalence, timing, and triggers of
ectopic adrenocorticotropic hormone syndrome in patients with olfactory neuroblastomas
remain unclear. This study aimed to investigate these factors and conduct a literature review.
Fifteen patients with olfactory neuroblastomas who underwent surgery at our institution were
included. The prevalence of ectopic adrenocorticotropic hormone syndrome development …