The beneficial effects of N-acetyl cysteine (NAC) against obesity associated complications: A systematic review of pre-clinical studies

PV Dludla, SE Mazibuko-Mbeje, TM Nyambuya… - Pharmacological …, 2019 - Elsevier
… a persistent link has been acknowledged between increased … reducing free fatty acid-induced
perilipin expression … inhibitory effect of lipid accumulation, amelioration of insulin resistance

[HTML][HTML] N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model

M Schuurman, M Wallace, G Sahi, M Barillaro… - Frontiers in …, 2022 - frontiersin.org
insulin resistance, where peripheral tissue insulin receptors become insensitive and require
increased insulin … changes, prolonged high fat diet (HFD)-induced compensation affects the …

Maternal N-acetyl cysteine intake improved glucose tolerance in obese mice offspring

M Michlin, L Argaev-Frenkel… - International Journal of …, 2020 - mdpi.com
… was to investigate the effects of N-acetyl-l-cysteine (NAC) given … developed due to this
chronic hyperinsulinemia, as found in … with NAC not only prevented insulin resistance, but also …

Redox status, inflammation, necroptosis and inflammasome as indispensable contributors to high fat diet (HFD)-induced neurodegeneration; Effect of N-acetylcysteine …

WA Keshk, MA Ibrahim, SM Shalaby, ZA Zalat… - Archives of biochemistry …, 2020 - Elsevier
Increased long term intake of HFD impairs whole body … may be due to increased level of
the circulating free fatty acids, as a … as NF-ϰB, inflammation and insulin resistance. Peripheral …

Effect of N-acetyl-L-cysteine prevention or intervention on diet induced beta cell compensation and dysfunction

M Wallace - 2019 - search.proquest.com
… Short- and long-term antioxidant treatment of T2DM with … stress levels in peripheral tissue
and improve insulin resistance … ) accumulation caused by increased intake of free fatty acids (…

Taurine and N-acetylcysteine treatments prevent memory impairment and metabolite profile alterations in the hippocampus of high-fat diet-fed female mice

AM Garcia-Serrano, JPP Vieira… - Nutritional …, 2023 - Taylor & Francis
… after glucose intolerance and insulin resistance were installed [… syndrome, without the
chronic insulin receptor stimulation in … have beneficial effects on HFD-induced alterations of …

[HTML][HTML] Effects of N-Acetyl-L-Cysteine on Serum Indices and Hypothalamic AMPK-Related Gene Expression Under Chronic Heat Stress

Z Li, Y Zhao, Y Zhuang, Z Xu, C Wu, P Liu… - Frontiers in Veterinary …, 2022 - frontiersin.org
… In the hypothalamus, AMPK participates in fatty acid … In our results, the changes in the
expression levels of these three … caused by heat stress, effectively reduce the decomposition of …

Akt Signaling and Nitric Oxide Synthase as Possible Mediators of the Protective Effect of N-acetyl-L-cysteine in Prediabetes Induced by Sucrose

MC Castro, HG Villagarcía, L Di Sarli Gutiérrez… - International Journal of …, 2024 - mdpi.com
… , insulin resistance, and oxidative stress, induced by a high … Finally, fatty acid synthase (FAS),
sterol regulatory element-… effects of NAC against metabolic dysregulations, chronic immune …

N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via …

M Delgobo, JP Agnes, RM Goncalves… - The Journal of nutritional …, 2019 - Elsevier
… evaluate the impact of short- (15 days) versus long-term (60 … , we also hypothesize that
pro-oxidant environments induced … serum total cholesterol, insulin resistance, adipose tissue …

[PDF][PDF] Evaluation of the effects of n-acetylcysteine on serum glucose, lipid profile, and body weight in rats with fructose-induced metabolic syndrome

AZ Yahya, GA Taqa, MA Alkataan - Military Medical Science …, 2023 - researchgate.net
… hepatic insulin resistance resulting from a prolonged exposure … Lipoprotein lipase mediated
fatty acid delivery and its impact in … N-Acetyl-L-Cysteine inhibits the development of glucose …