Switching antidepressants in the treatment of major depression: when, how and what to switch to?

P Boyce, M Hopwood, G Morris, A Hamilton… - Journal of affective …, 2020 - Elsevier
… , augmentation with another agent or switching … in switching across class for patients
with SSRI resistant depression with a 4.5% difference in remission rates comparing switching

Effect of antidepressant switching between nortriptyline and escitalopram after a failed first antidepressant treatment among patients with major depressive disorder

O Köhler-Forsberg, ER Larsen… - The British Journal of …, 2019 - cambridge.org
… with MDD and non-response to at least one antidepressant course,12 found that
augmentation with aripiprazole showed significant better remission compared with individuals …

[HTML][HTML] Remission and treatment augmentation of depression in the United States

R Mojtabai, M Amin-Esmaeili, S Spivak… - The Journal of clinical …, 2021 - psychiatrist.com
… correlates of depression non-remission and antidepressant augmentation treatment use …
non-remission and medication augmentation treatment in individuals receiving antidepressant

Characteristics of patients with major depressive disorder switching SSRI/SNRI therapy compared with those augmenting with an atypical antipsychotic in a real-world …

DM Kern, MS Cepeda… - Current Medical …, 2021 - Taylor & Francis
… attain remissionCitation 6 . … between patients who augment versus switch therapy are
unknown. The choice to receive treatment augmentation versus switching to a new antidepressant

[HTML][HTML] Antidepressant augmentation versus switch in treatment-resistant geriatric depression

EJ Lenze, BH Mulsant, SP Roose… - … England Journal of …, 2023 - Mass Medical Soc
… incidence of remission. Among patients in whom augmentation or a switch to bupropion …
remission with lithium augmentation or a switch to nortriptyline were similar. (Funded by the …

What to expect when switching to a second antidepressant medication following an ineffective initial SSRI: a report from the randomized clinical STAR* D study

AJ Rush, C South, MK Jha, SB Jain… - The Journal of clinical …, 2020 - psychiatrist.com
… to a different treatment rather than augmenting their initial … /remission occur in those who
will respond or remit?” or “Can we identify early the patients for whom a second-step switch

Effects of Discontinuation of Drugs Used for Augmentation Therapy on Treatment Outcomes in Depression: A Systematic Review and Meta-analysis

H Kato, T Koizumi, H Takeuchi, H Tani… - …, 2021 - thieme-connect.com
… and augmentation drugs, after they exhibited remission … the effect of discontinuing ketamine
used as an augmentation … Moreover, this study included an antidepressant switch when …

Combining antidepressants vs antidepressant monotherapy for treatment of patients with acute depression: a systematic review and meta-analysis

J Henssler, D Alexander, G Schwarzer, T Bschor… - JAMA …, 2022 - jamanetwork.com
… agents, response rates to initial antidepressant monotherapy hover at 60%, and remissions
… On the whole, in our analysis, treatment effects of antidepressant combinations were not …

Continuation phase treatment outcomes for switching, combining, or augmenting strategies for treatment‐resistant major depressive disorder: A VAST‐D report

S Zisook, GR Johnson, P Hicks, P Chen… - Depression and …, 2021 - Wiley Online Library
… : switch the index antidepressant to bupropion SR (S-BUP), combine the index … in remission
at Week 12, there were no significant differences in cumulative emergent remission between

Nonpharmacologic and pharmacologic treatments of adult patients with major depressive disorder: a systematic review and network meta-analysis for a clinical …

G Gartlehner, A Dobrescu, A Chapman… - Annals of internal …, 2023 - acpjournals.org
… For patients who have intolerable side effects or who do not … and include switching
antidepressants or augmenting them … no difference in remission between treatment groups (Figure …