Immunothrombosis and the role of platelets in venous thromboembolic diseases

M Heestermans, G Poenou, AC Duchez… - … Journal of Molecular …, 2022 - mdpi.com
… Furthermore, the role of platelets in coagulation, fibrinolysis, … The platelet endothelial cell
adhesion molecule-1 (PECAM-1) is a … the effects of P2Y12 antagonists, mainly clopidogrel, on …

[PDF][PDF] The frequency of aspirin and clopidogrel resistance and related factors in patients undergoing elective percutaneous coronary intervention

D Karabulut, A Kaya, O Abacı, U Karabulut, FN Turhan… - EJCM, 2021 - academia.edu
… (26.8%) with clopidogrel resistance. Female gender, DM, HL, and family history for
ischemic heart disease were significantly more frequent among clopidogrel resistant patients, …

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This …

I Bararu Bojan, S Dobreanu, MC Vladeanu… - … Journal of Molecular …, 2024 - mdpi.com
… a result of the coagulation cascade activated by subendothelial … to accelerate the rate of
fibrinolysis and bleeding, while … increasing the expression of adhesion molecules on their surface…

Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target

M Ziegler, X Wang, K Peter - Cardiovascular research, 2019 - academic.oup.com
… pivotal role in thrombosis and haemostasis are well known and … of clopidogrel to its active
metabolite may explain its failure … PCI after failed fibrinolysis demonstrated the superiority of …

Antiplatelets, Anticoagulants, and Fibrinolytics

GM Raj - Introduction to Basics of Pharmacology and Toxicology …, 2021 - Springer
… prevention of atherosclerotic cardiovascular disease (ASCVD) … a prodrug like clopidogrel;
however, the onset of action is … activation of the coagulation and fibrinolytic pathways are …

Novel antiplatelet therapies for atherothrombotic diseases

A Majithia, DL Bhatt - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
… efficacy while preserving hemostasis, holds tremendous … study of the effects of ticagrelor,
prasugrel, and clopidogrel on … coronary syndrome or high-risk coronary artery disease.Eur …

Impaired Spontaneous/Endogenous Fibrinolytic Status as New Cardiovascular Risk Factor? JACC Review Topic of the Week

DA Gorog, GYH Lip - Journal of the American College of Cardiology, 2019 - jacc.org
… activation of platelets, coagulation, and fibrinolysis. Lysis of … cardiovascular events (MACEs;
a composite of heart attack, … Thrombosis Test before and during clopidogrel, ticagrelor, or …

Platelets in the Pathogenesis of Vascular Disease and Their Role as a Therapeutic Target

J McFadyen, K Peter - Mechanisms of Vascular Disease: A Textbook for …, 2020 - Springer
… that underpin physiological haemostasis may become … and expression of adhesion molecules
such as ICAM-1, VCAM-… with the use of anti-fibrinolytics, such as tranexamic acid, platelet …

First Human Use of RUC‐4: A Nonactivating Second‐Generation Small‐Molecule Platelet Glycoprotein IIb/IIIa (Integrin αIIbβ3) Inhibitor Designed for Subcutaneous …

DJ Kereiakes, TD Henry, AN DeMaria… - … of the American Heart …, 2020 - Am Heart Assoc
… patients with stable coronary artery disease receiving aspirin … In patients with coronary
artery disease, 15 minutes after … , 33 Pharmacologic interventions (both fibrinolysis and platelet …

Platelet inhibition in acute coronary syndrome and percutaneous coronary intervention: insights from the past and present

DA Gorog, T Geisler - Thrombosis and haemostasis, 2020 - thieme-connect.com
… died from sudden death due to ischemic heart disease, plaque disruption with overlying …
has similar antithrombotic effects to clopidogrel, albeit with minimal effect on hemostasis[105] …