Impact of hepatitis B virus genetic variation, integration, and lymphotropism in antiviral treatment and oncogenesis

KCK Lau, KW Burak, CS Coffin - Microorganisms, 2020 - mdpi.com
Chronic Hepatitis B Virus (HBV) infection poses a significant global health burden.
Although, effective treatment and vaccinations against HBV are available, challenges still exist, …

Characteristics of regulatory T‐cell function in patients with chronic hepatitis B and C coinfection

CW Tseng, SF Wu, CY Chen, YC Ho… - … of Viral Hepatitis, 2020 - Wiley Online Library
… Second, some cytokines important for chronic viral infection were not included in this study.
Our results therefore cannot provide a whole picture of the dynamic changes occurring in …

Dynamic changes of the proportion of HLA-DR and CD38 coexpression subsets on T lymphocytes during IFN-based chronic hepatitis B treatment

Y Lin, G Shen, S Xie, X Bi, H Lu, L Yang… - Frontiers in …, 2023 - frontiersin.org
… role in virus clearance (13–15). Immature T lymphocytes express the transmembrane
glycoproteins human leukocyte … Although patients with CHB had a chronic virus infection, IFN

Insufficient immunity led to virologic breakthrough in NAs-treated chronic hepatitis B patients switching to Peg–IFN–ɑ

D Huang, W Yan, M Han, W Yuan, P Wang, Y Chen… - Antiviral Research, 2022 - Elsevier
… course of pegylated interferon alpha (Peg–IFN–ɑ) … IFN–ɑ in hepatitis B e antigen (HBeAg)
positive patients who had achieved virologic suppression but not seroconverted to hepatitis B

Tumor-infiltrating leukocyte composition and prognostic power in hepatitis B-and hepatitis C-related hepatocellular carcinomas

YW Hsiao, LT Chiu, CH Chen, WL Shih, TP Lu - Genes, 2019 - mdpi.com
… Although the majority of liver malignancy is related to viral hepatitis B (HBV) or C (HCV) [2],
there are many differences between the two types of HCC in terms of activated pathways [3], …

Peripheral immune characteristics of hepatitis B virus-related hepatocellular carcinoma

R Sun, J Li, X Lin, Y Yang, B Liu, T Lan, S Xiao… - Frontiers in …, 2023 - frontiersin.org
… of human leukocyte antigen DR (HLA-DR) and CD38 is related to the activation of CD8 +
T cells, and the circulating activated CD8 + T cells (CD38 + HLADR + ) in patients with HBV-…

Strong association of functional polymorphism in IL‐12B with susceptibility to chronic hepatitis B in Tunisia

I Ben Dhifallah, K Ayouni, H Jmel… - Journal of Medical …, 2021 - Wiley Online Library
… that affect expression of cytokines that regulate and initiate the immune system such as IL-12B
may reduce the ability of the immune system to elicit a response against viral infections. …

Genetic association of interleukin-6 polymorphism (rs1800796) with chronic hepatitis B virus infection in Chinese Han population

M Li, Y Zhuo, Y Xu, H Chen, Z Cheng, L Zhou - Viral Immunology, 2021 - liebertpub.com
… In addition, numerous studies have explored the associations between polymorphisms in
candidate genes and HBV infection, including human leukocyte antigen, cytokines, and …

Factors associated with hepatitis B surface antigen kinetics and responses in pegylated interferon alpha-2a monotherapy for patients with chronic hepatitis B

N Itokawa, M Atsukawa, A Tsubota, N Shimada… - Internal …, 2021 - jstage.jst.go.jp
… A total of 50 patients with chronic hepatitis B were subjected to the current … Long-term effects
of peginterferon alfa-2a therapy in Japanese patients with chronic hepatitis B virus infection. …

[HTML][HTML] Multi-parametric analysis of human livers reveals variation in intrahepatic inflammation across phases of chronic hepatitis B infection

…, S Turner, L Diehl, L Li, JD Debes, B Feierbach… - Journal of …, 2022 - Elsevier
… up to 15% of the intrahepatic leukocytes, 39 , 40 and their functional status warrants further
investigation. However, other chronic viral infections such as HIV and HCV are associated …