Effect of molecular crowding on the stability of RNA G-quadruplexes with various numbers of quartets and lengths of loops

S Matsumoto, H Tateishi-Karimata, S Takahashi… - Biochemistry, 2020 - ACS Publications
stability of RNA G-quadruplexes with different numbers of G-quartets and lengths of loops
under … indicate that RNA G-quadruplexes with different numbers of G-quartets exhibit different …

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back

P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
… the core of the G-quartets, G4 stability is only slightly affected … tools, the nature of the loop is
considered a key parameter; … in propeller loops, y = 2 causes deformation of the G-quartets if …

Effects of central loop length and metal ions on the thermal stability of G-quadruplexes

F Hao, Y Ma, Y Guan - Molecules, 2019 - mdpi.com
… The G4 consists of stacked G-quartets (also named G-tetrads), each of which consists of …
The G-quartets in G4 structure stack together linked with two side loops and one central loop. …

Stability factors of the parallel quadruplexes: DNA versus RNA

B Kankia - The Journal of Physical Chemistry B, 2019 - ACS Publications
… -reversal loops play an important role in higher stability of RNAstabilization effect that
should be due to the structural rigidity of RNA or/and stabilizing effect the chain-reversal loops

Thermodynamic stability of Gquadruplexes: impact of sequence and environment

J Jana, K Weisz - ChemBioChem, 2021 - Wiley Online Library
… of cations between the G-quartets. Early calorimetric studies … G-quadruplexes are directly
tied to the progression of loops … by three propeller loops, lateral/diagonal loops link two adjacent…

Quantitative Effects of the Loop Region on Topology, Thermodynamics, and Cation Binding of DNA G-quadruplexes

M Nakata, N Kosaka, K Kawauchi, D Miyoshi - ACS omega, 2024 - ACS Publications
stability of G-quadruplexes is important for their biological roles. G-quadruplexes are stable
in … that the number of G-quartets and the configuration of the guanine bases affect the binding …

Guiding the folding of G-quadruplexes through loop residue interactions

J Jana, YM Vianney, N Schröder… - Nucleic Acids …, 2022 - academic.oup.com
Stabilization of a lateral loop through outer tetrad stacking of a loop 3′-purine but also the
importance of steric effects … on the effect of 1-nt loops on G4 folding, the gain in stability of the …

Stability of two-quartet G-quadruplexes and their dimers in atomistic simulations

B Islam, P Stadlbauer, M Vorlickova… - Journal of Chemical …, 2020 - ACS Publications
… The stability of GQs increases with the number of G-quartets, … although stable antiparallel
two-quartet GQs with loop alignments … effect of the increasing number of G-quartets in the stem. …

Conformational dynamics of the RNA G-quadruplex and its effect on translation efficiency

T Endoh, N Sugimoto - Molecules, 2019 - mdpi.com
… discuss the dynamic behavior of RNA G-quadruplexes in cells [36]. … , which connect the
guanine tracts involved in G-quartets … of thermodynamically stable G-quadruplexes during protein …

Folding kinetics of G-quadruplexes: Duplex stem loops drive and accelerate G-quadruplex folding

TQN Nguyen, KW Lim, AT Phan - The Journal of Physical …, 2020 - ACS Publications
… the loops could have a positive effect on the thermal stability of … First, we investigate the effect
of the experimental conditions … the effect of various properties of a loop including loop length…