mGluR2 positive allosteric modulators: an updated patent review (2013–2018)
AA Trabanco, JM Bartolomé, JM Cid - Expert opinion on therapeutic …, 2019 - Taylor & Francis
… continue to be explored and AZD8529 is currently in a phase … showed good metabolic
stability after incubation with human … ketamine- and methamphetamine – increased locomotor …
stability after incubation with human … ketamine- and methamphetamine – increased locomotor …
The role of metabotropic glutamate receptors in neurobehavioral effects associated with methamphetamine use
PU Hámor, LA Knackstedt, M Schwendt - International Review of …, 2023 - Elsevier
… of novel pharmacotherapies for Methamphetamine Use Disorder based on the selective
modulation mGlu … explored using mGlu5 positive allosteric modulators (PAMs); see below. …
modulation mGlu … explored using mGlu5 positive allosteric modulators (PAMs); see below. …
ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking
JM Illenberger, FJ Flores-Ramirez, A Matzeu… - …, 2023 - Elsevier
… after day 6 of AZD8529 treatment, suggesting that the beneficial effect of reducing drug
self-administration may outlast some off-target effects on other consummatory behaviors (Li et al., …
self-administration may outlast some off-target effects on other consummatory behaviors (Li et al., …
Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations
KA Johnson, DM Lovinger - Advances in Pharmacology, 2020 - Elsevier
… Positive allosteric modulators (PAMs) of mGlu 2 and negative allosteric modulators of mGlu
5 … behaviors represents an important strategy for identifying novel therapeutic mechanisms. …
5 … behaviors represents an important strategy for identifying novel therapeutic mechanisms. …
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
SH Li, KS Abd-Elrahman, SSG Ferguson - Pharmacology & therapeutics, 2022 - Elsevier
… In this review, we discuss what is currently known regarding the contribution of mGluR2 and
… the allosteric site, they can either enhance glutamate response (positive allosteric modulator…
… the allosteric site, they can either enhance glutamate response (positive allosteric modulator…
Advances in translating mGlu2 and mGlu3 receptor selective allosteric modulators as breakthrough treatments for affective disorders and alcohol use disorder
… negative allosteric modulators show acute antidepressant-like … of novel mGlu 2 and mGlu
3 negative allosteric modulators. … In the schizophrenia trials, AZD8529 did not affect primary …
3 negative allosteric modulators. … In the schizophrenia trials, AZD8529 did not affect primary …
Adaptive changes in group-II metabotropic glutamate receptors underlie the deficit in recognition memory induced by methamphetamine in mice
CL Busceti, L Di Menna, S Castaldi, G D'Errico… - eNeuro, 2024 - eneuro.org
… challenged with methamphetamine was corrected by systemic treatment with selectively
85 negative allosteric modulators of mGlu2 or mGlu3 receptors (compounds VU6001966 and …
85 negative allosteric modulators of mGlu2 or mGlu3 receptors (compounds VU6001966 and …
Neural mechanisms underlying incubation of methamphetamine craving: a mini-review
RD Altshuler, H Lin, X Li - Pharmacology Biochemistry and Behavior, 2020 - Elsevier
… This review focuses on causal studies on incubation of methamphetamine craving. … Positive
allosteric modulator Ligands that bind to an allosteric binding site on a receptor, resulting in …
allosteric modulator Ligands that bind to an allosteric binding site on a receptor, resulting in …
Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice
CL Busceti, RP Ginerete, L Di Menna, G D'Errico… - …, 2021 - Elsevier
… receptor positive allosteric modulator (PAM), AZD8529, … with methamphetamine (5 μM) 10
min after the incubation with … into novel therapeutic options for methamphetamine addiction. …
min after the incubation with … into novel therapeutic options for methamphetamine addiction. …
A mechanistic overview of approaches for the treatment of psychostimulant dependence
KL Jensen, SB Jensen, KL Madsen - Frontiers in Pharmacology, 2022 - frontiersin.org
… mechanism of action of the atypical DAT inhibitors might provide novel … positive allosteric
modulator of mGluR2, AZD8529, has been shown to decrease incubation of methamphetamine …
modulator of mGluR2, AZD8529, has been shown to decrease incubation of methamphetamine …