The effects of growth hormone on adipose tissue: old observations, new mechanisms

JJ Kopchick, DE Berryman, V Puri, KY Lee… - Nature Reviews …, 2020 - nature.com
… the lipolytic effects of GH in adipose tissue with an emphasis on studies in humans. We also
… antagonistic effects of GH on insulin-stimulated muscle glucose uptake 7,8 . In addition to …

Effect of growth hormone on insulin signaling

R Sharma, JJ Kopchick, V Puri, VM Sharma - Molecular and cellular …, 2020 - Elsevier
… In this review, we will provide an update on GH-stimulated adipose lipolysis and its
consequences on insulin signaling in liver, skeletal muscle, and adipose tissue. Furthermore, we will …

[HTML][HTML] Regulation of GH and GH Signaling by Nutrients

M Caputo, S Pigni, E Agosti, T Daffara, A Ferrero… - Cells, 2021 - mdpi.com
… inhibitory effects of IGF-I on GH and block the stimulatory effects … in the muscle [98] and,
partly, in the liver [1]. However, … of GH on lipid metabolism result in a reduction in body-fat mass, …

Insulin and growth hormone balance: implications for obesity

Z Huang, L Huang, MJ Waters, C Chen - Trends in Endocrinology & …, 2020 - cell.com
effects in glucose and lipid metabolism of insulin and GH are shown in yellow and red,
respectively. The synergistic effects of insulin and GH … that the physiological effects of JAK2-PI3K/…

[HTML][HTML] Links between testosterone, oestrogen, and the growth hormone/insulin-like growth factor axis and resistance exercise muscle adaptations

N Gharahdaghi, BE Phillips, NJ Szewczyk… - Frontiers in …, 2021 - frontiersin.org
… hormonal responses and their impact on muscle adaptation, we aim to … effects that GH
has on muscle mass, GH receptor knock-out results in a decrease in myofiber CSA and muscle

[HTML][HTML] Growth hormone (s), testosterone, insulin-like growth factors, and cortisol: roles and integration for cellular development and growth with exercise

WJ Kraemer, NA Ratamess, WC Hymer… - Frontiers in …, 2020 - frontiersin.org
GH in the rat pituitary and/or circulation (including human … had a more significant impact
on future GH research efforts than … Within skeletal muscle it regulates lipid utilization (234), …

[HTML][HTML] Skeletal muscle hypertrophy, insulin-like growth factor 1, myostatin and follistatin in healthy and sarcopenic elderly men: the effect of whole-body resistance …

R Negaresh, R Ranjbar, JS Baker… - … journal of preventive …, 2019 - journals.lww.com
… loss of muscle function and … muscle.[ 9 ] Transgenic mice with disruption of the MSTN gene
developed a 2- to 3-fold increase in muscle mass with no corresponding increase in adipose

GH knockout mice have increased subcutaneous adipose tissue with decreased fibrosis and enhanced insulin sensitivity

EO List, DE Berryman, M Buchman, EA Jensen… - …, 2019 - academic.oup.com
… Visceral organs (eg, kidney, heart, spleen) and skeletal muscle are … and fat mass. Thus,
results of this study not only provide insight into GH’s effect on glucose metabolism and adipose

… Insulinotropic Polypeptide (GIP) on human adipose tissue and fat metabolism: Implications for obesity, type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD …

SK Thondam, DJ Cuthbertson, JPH Wilding - Peptides, 2020 - Elsevier
effects of GIP on fat metabolism in human adipose and other non-adipose tissues such as
liver, pancreas, skeletal muscle … insulin, catecholamines, growth hormone and glucocorticoids […

[HTML][HTML] The effect of exercise on glucoregulatory hormones: A countermeasure to human aging: Insights from a comprehensive review of the literature

M Sellami, NL Bragazzi, M Slimani, L Hayes… - International journal of …, 2019 - mdpi.com
… cortisol, growth hormone and insulin. As such, this review examines the effects of endurance,
… Insulin plays a key role in glucose uptake by muscle, fat, and liver cells. Moreover, insulin …