Once-weekly somapacitan is effective and well tolerated in adults with GH deficiency: a randomized phase 3 trial

G Johannsson, MB Gordon… - The Journal of …, 2020 - academic.oup.com
… of somapacitan were in accordance with well-recognized effects of GH replacement, with a
reduction in abdominal fat mass and an increase in skeletal muscle mass. Somapacitan may …

… Insulinotropic Polypeptide (GIP) on human adipose tissue and fat metabolism: Implications for obesity, type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD …

SK Thondam, DJ Cuthbertson, JPH Wilding - Peptides, 2020 - Elsevier
effects of GIP on fat metabolism in human adipose and other non-adipose tissues such as
liver, pancreas, skeletal muscle … insulin, catecholamines, growth hormone and glucocorticoids […

Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines

B Kirk, J Feehan, G Lombardi, G Duque - Current osteoporosis reports, 2020 - Springer
adipose tissue and the secretion of adipokines (derived from adipocytes). In this review, we
discuss the bidirectional effects of myokines and osteokines on musclegrowth hormone (GH)…

[HTML][HTML] Impact of skeletal muscle mass on metabolic health

G Kim, JH Kim - Endocrinology and Metabolism, 2020 - synapse.koreamed.org
… from loss of skeletal muscle mass increases lipolysis and the consequent release of free
fatty acids from adipose tissue, which leads to inhibition of the growth hormone/insulin growth …

New findings on brain actions of growth hormone and potential clinical implications

J Donato Jr, JJ Kopchick - Reviews in Endocrine and Metabolic Disorders, 2024 - Springer
adipose tissue, and skeletal muscle, the diabetogenic effect of GH is thought to be mediated
by a direct effect … by the lipolytic effect of GH is considered the main factor contributing to GH-…

The use and abuse of growth hormone in sports

RIG Holt, KKY Ho - Endocrine reviews, 2019 - academic.oup.com
… marked effects on body composition (3, 4), but by then, GH had … body lipid oxidation reflects
the action of GH on skeletal muscle. … as well as humans, suggesting that GH action is tissue …

Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice

CS Wu, Q Wei, H Wang, DM Kim… - The Journals of …, 2020 - academic.oup.com
… secretagogue of GH that regulates muscle growth and differentiation through the GH–insulin…
capacity and reduces triglyceride deposition in the muscles of high-fat diet fed rats (31). …

Exercise and the GH-IGF-I axis

A Eliakim, D Nemet - Endocrinology of physical activity and sport, 2020 - Springer
… relatively unused muscle group) but which had no effect on … The effect of prior high-fat meal
ingestion appeared to be GH … of high-fat meal attenuated the magnitude of GH response to …

Effects of GH/IGF axis on bone and cartilage

M Dixit, SB Poudel, S Yakar - Molecular and cellular endocrinology, 2021 - Elsevier
… -1 (75%), while other tissues, such as fat and muscle, contribute ~25% of IGF-1 in … human
trabecular bone and cultured in lipogenic medium— provided with GH, showed inhibited lipid

Ghrelin regulation of glucose metabolism

SM Gray, LC Page, J Tong - Journal of neuroendocrinology, 2019 - Wiley Online Library
… brain, the action of ghrelin increases growth hormone (GH) and … The effect of ghrelin on the
action of insulin in muscle and fat … glucose uptake into the skeletal muscle.109 An opposite …