Statins and the brain: more than lipid lowering agents?

A Fracassi, M Marangoni, P Rosso… - Current …, 2019 - ingentaconnect.com
… , particularly in large cells such as the dopaminergic neurons … fraction in the hippocampus
and prefrontal cortex, two brain … due not only to the different statin dosage used in each experi…

[HTML][HTML] Update on statin treatment in patients with neuropsychiatric disorders

R Avan, A Sahebnasagh, J Hashemi, M Monajati… - Life, 2021 - mdpi.com
… administration of a selective serotonin reuptake-inhibitor (SSRI) [… statins have an influence
on the dopamine neurotransmitter and decreases dopamine concentrations in the prefrontal

Effects of statins on dopamine loss and prognosis in Parkinson's disease

SH Jeong, HS Lee, SJ Chung, HS Yoo, JH Jung… - Brain, 2021 - academic.oup.com
levels. This study suggests that statin use may have a detrimental effect on baseline
nigrostriatal dopamine degeneration and long-term outcomes in patients with Parkinson’s disease. …

Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-α in patients with major depressive disorder

K Liu, X Zhao, X Lu, X Zhu, H Chen, M Wang… - Psychological …, 2019 - cambridge.org
… may play a role in disturbing the effect of selective serotonin reuptake inhibitor (SSRI) on the
… patients, and to evaluate the effect of TNF-α level on these abnormal connectivities during …

[HTML][HTML] The pharmacological bases for repurposing statins in depression: a review of mechanistic studies

R De Giorgi, N Rizzo Pesci, G Rosso, G Maina… - Translational …, 2023 - nature.com
Simvastatin also increases serotonin reuptake by … Indeed, the dopaminergic system appears
affected by statins … mevalonate metabolites within the hippocampus and prefrontal cortex of …

[HTML][HTML] The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

YM Vuu, A Kadar Shahib, M Rastegar - Pharmaceuticals, 2023 - mdpi.com
… In this review, we outline the potential therapeutic effects of simvastatin on brain … D2
receptors for dopamine. The authors proposed that the molecular effect of simvastatin on inducing …

Aiding and abetting anhedonia: impact of inflammation on the brain and pharmacological implications

MJ Lucido, M Bekhbat, DR Goldsmith… - Pharmacological …, 2021 - ASPET
… to these effects of inflammation, including decreased synthesis, release and reuptake of
dopamine, … and ventromedial prefrontal cortex. Neurocircuitry changes in turn mediate nuanced …

Monoamine oxidase B total distribution volume in the prefrontal cortex of major depressive disorder: an [11C] SL25. 1188 positron emission tomography study

S Moriguchi, AA Wilson, L Miler, PM Rusjan… - JAMA …, 2019 - jamanetwork.com
… downstream consequences poorly targeted by the common selective serotonin reuptake
through formation of dopaminochrome from dopamine. Reduced mitochondrial complex 1 …

The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies

V Dionisie, GA Filip, MC Manea, M Manea… - Inflammopharmacology, 2021 - Springer
… An important mechanism is the disruption of serotonin, dopaminereuptake inhibitors (SSRIs)
and serotonin–noradrenaline … in the hippocampus and prefrontal cortex are downregulated …

Repeated ethanol exposure influences key enzymes in cholesterol and lipid homeostasis via the AMPK pathway in the rat prefrontal cortex

S Xu, SJ Jeong, G Li, JW Koo, UG Kang - Alcohol, 2020 - Elsevier
… is indirectly affected by dopamine. In the prefrontal cortex, where dopamine D 1 receptors
are abundant relative to dopamine D 2 receptors, the dopamine reuptake inhibitor, cocaine, …