Statins and the brain: more than lipid lowering agents?
A Fracassi, M Marangoni, P Rosso… - Current …, 2019 - ingentaconnect.com
… , particularly in large cells such as the dopaminergic neurons … fraction in the hippocampus
and prefrontal cortex, two brain … due not only to the different statin dosage used in each experi…
and prefrontal cortex, two brain … due not only to the different statin dosage used in each experi…
[HTML][HTML] Update on statin treatment in patients with neuropsychiatric disorders
… administration of a selective serotonin reuptake-inhibitor (SSRI) [… statins have an influence
on the dopamine neurotransmitter and decreases dopamine concentrations in the prefrontal …
on the dopamine neurotransmitter and decreases dopamine concentrations in the prefrontal …
Effects of statins on dopamine loss and prognosis in Parkinson's disease
… levels. This study suggests that statin use may have a detrimental effect on baseline
nigrostriatal dopamine degeneration and long-term outcomes in patients with Parkinson’s disease. …
nigrostriatal dopamine degeneration and long-term outcomes in patients with Parkinson’s disease. …
Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-α in patients with major depressive disorder
K Liu, X Zhao, X Lu, X Zhu, H Chen, M Wang… - Psychological …, 2019 - cambridge.org
… may play a role in disturbing the effect of selective serotonin reuptake inhibitor (SSRI) on the
… patients, and to evaluate the effect of TNF-α level on these abnormal connectivities during …
… patients, and to evaluate the effect of TNF-α level on these abnormal connectivities during …
[HTML][HTML] The pharmacological bases for repurposing statins in depression: a review of mechanistic studies
… Simvastatin also increases serotonin reuptake by … Indeed, the dopaminergic system appears
affected by statins … mevalonate metabolites within the hippocampus and prefrontal cortex of …
affected by statins … mevalonate metabolites within the hippocampus and prefrontal cortex of …
[HTML][HTML] The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action
YM Vuu, A Kadar Shahib, M Rastegar - Pharmaceuticals, 2023 - mdpi.com
… In this review, we outline the potential therapeutic effects of simvastatin on brain … D2
receptors for dopamine. The authors proposed that the molecular effect of simvastatin on inducing …
receptors for dopamine. The authors proposed that the molecular effect of simvastatin on inducing …
Aiding and abetting anhedonia: impact of inflammation on the brain and pharmacological implications
… to these effects of inflammation, including decreased synthesis, release and reuptake of
dopamine, … and ventromedial prefrontal cortex. Neurocircuitry changes in turn mediate nuanced …
dopamine, … and ventromedial prefrontal cortex. Neurocircuitry changes in turn mediate nuanced …
Monoamine oxidase B total distribution volume in the prefrontal cortex of major depressive disorder: an [11C] SL25. 1188 positron emission tomography study
… downstream consequences poorly targeted by the common selective serotonin reuptake …
through formation of dopaminochrome from dopamine. Reduced mitochondrial complex 1 …
through formation of dopaminochrome from dopamine. Reduced mitochondrial complex 1 …
The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies
… An important mechanism is the disruption of serotonin, dopamine… reuptake inhibitors (SSRIs)
and serotonin–noradrenaline … in the hippocampus and prefrontal cortex are downregulated …
and serotonin–noradrenaline … in the hippocampus and prefrontal cortex are downregulated …
Repeated ethanol exposure influences key enzymes in cholesterol and lipid homeostasis via the AMPK pathway in the rat prefrontal cortex
… is indirectly affected by dopamine. In the prefrontal cortex, where dopamine D 1 receptors
are abundant relative to dopamine D 2 receptors, the dopamine reuptake inhibitor, cocaine, …
are abundant relative to dopamine D 2 receptors, the dopamine reuptake inhibitor, cocaine, …