Dosing of losartan in men versus women with heart failure with reduced ejection fraction: the HEAAL trial

JP Ferreira, MA Konstam, JJV McMurray… - … Journal of Heart …, 2021 - Wiley Online Library
Low-Dose Losartan on Clinical Outcomes in Patients with … The present study shows that
men appeared to have benefited more from high-dose (compared with low-dose) losartan, …

High-versus low-dose losartan and uric acid: An analysis from HEAAL

JP Ferreira, F Zannad, MS Kiernan, MA Konstam - Journal of Cardiology, 2023 - Elsevier
… to low-dose, high-dose losartan reduced the composite of HF hospitalization or cardiovascular
low-dose losartan on gout, because low-dose losartan might have already mitigated the …

High-Versus Low-dose Losartan and Serum Potassium: An Analysis From HEAAL

JP Ferreira, M Konstam, P Rossignol, MS Kiernan… - Journal of Cardiac …, 2023 - Elsevier
… The effects of high-dose vs low-dose losartan on clinical outcomes in patients with heart
, renin-angiotensin-aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic …

Evaluating sacubitril/valsartan dose dependence on clinical outcomes in patients with heart failure with reduced ejection fraction

K Kido, C Bianco, M Caccamo… - Annals of …, 2021 - journals.sagepub.com
… The ATLAS trial compared the low-dose lisinopril group with the high-dose lisinopril … outcome
was the composite of all-cause mortality and hospitalization for HF. The high-dose losartan

[HTML][HTML] Higher versus lower doses of ACE inhibitors, angiotensin-2 receptor blockers and beta-blockers in heart failure with reduced ejection fraction: Systematic …

RD Turgeon, MR Kolber, P Loewen, U Ellis… - PloS one, 2019 - journals.plos.org
… For safety outcomes, we pooled trials within and across drug … high dose as the experimental
intervention and low dose as … efficacy outcomes, we reported fixed-effects model results for …

Dose-response to sacubitril/valsartan in patients with heart failure and reduced ejection fraction

R Mohebi, Y Liu, IL Piña, MF Prescott, J Butler… - Journal of the American …, 2022 - jacc.org
Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart
failure (HEAAL study): a randomised, double-blind trial". Lancet 2009;374:1840-1848. …

[HTML][HTML] How do we define high and low dose intensity of heart failure medications: a scoping review

MJ Kwak, Q Wang, C Onyebeke, T Holder… - BMC Cardiovascular …, 2023 - Springer
… irbesartan (low dose ≤ 150 mg and high dose > 150 mg), olmesartan (… We found a similar
pattern for ARBs, with losartan being the most … of dose intensity on key clinical outcomes. …

Association between dosing and combination use of medications and outcomes in heart failure with reduced ejection fraction: data from the S wedish Heart Failure …

D D'Amario, D Rodolico, GMC Rosano… - … Journal of Heart …, 2022 - Wiley Online Library
… High (32.5–35 mg) versus low dose (2.5–5 mg) of … 16 and high dose (150 mg) versus low
dose (50 mg) of losartan led to lower risk of all-cause death and HF hospitalization in the Heart

The Role of Drug Therapy in Lowering Mortality and Morbidity: From Established Heart Failure to High-Risk Hypertension

N Mistry, SE Kjeldsen, A Westheim - Hypertension and Heart Failure …, 2019 - Springer
… the two groups, but losartan was significantly better tolerated. In the … high-dose versus
low-dose losartan on clinical outcomes in patients with heart failure (HEAAL), 3846 patients

Comparative effectiveness of dosing of medical therapy for heart failure: from the CHAMP-HF registry

SJ Greene, J Butler, AS Hellkamp, JA Spertus… - Journal of Cardiac …, 2022 - Elsevier
… assessed associations between medication dosing and clinical outcomes over 24 months
(all-cause mortality, HF hospitalization) and patient-reported outcomes at 12 months (change …