Antidepressant-like properties of intrastriatal botulinum neurotoxin-a injection in a unilateral 6-ohda rat model of parkinson's disease

V Antipova, C Holzmann, A Hawlitschka, M Witt… - Toxins, 2021 - mdpi.com
… Therefore, in the present study, we aimed to examine a possible therapeutic effect of
intrastriatal injections of BoNT-A on depression-like behavior in the hemi-PD rat model induced by …

Repeated intrastriatal application of botulinum neurotoxin-A did not influence choline acetyltransferase-immunoreactive interneurons in hemiparkinsonian rat brain–A …

A Hawlitschka, C Berg, O Schmitt, C Holzmann, A Wree… - Brain Research, 2020 - Elsevier
… when injected intrastriatally. In hemiparkinsonian (hemi-PD) rats, a unilateral intrastriatal
injection … -induced rotation behavior for at least 3 months, the effect fading thereafter. A second …

Botulinum neurotoxin-a injected intrastriatally into hemiparkinsonian rats improves the initiation time for left and right forelimbs in both forehand and backhand …

V Antipova, C Holzmann, A Hawlitschka… - International Journal of …, 2019 - mdpi.com
… ITs and rotational behavior in hemi-PD rats dependent on post … and independently influenced
by intrastriatal BoNT-A. … possibly beneficial effect of repeated unilateral intrastriatal BoNT-…

Lasting peripheral and central effects of botulinum toxin type A on experimental muscle hypertonia in rats

P Šoštarić, B Vukić, L Tomašić, I Matak - International journal of molecular …, 2022 - mdpi.com
… Herein, we examined the long-term effects of intramuscularly injected BoNT-A by behavioral
scoring methods for the evaluation of both flaccid and spastic paralysis and locomotor …

Interlinking potential therapy with botulinum neurotoxin-A and Parkinson's disease

A Wree, A Hawlitschka, C Holzmann, M Witt… - … and Management in …, 2020 - Elsevier
Intrastriatal injections of botulinum neurotoxin-A in 6-hydroxydopamine-induced … to
morphological and behavioral outcomes. In naive rats, a mild effect of botulinum neurotoxin-A could …

Olfactory Bulb D2/D3 Receptor Availability after Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease

T Alberts, V Antipova, C Holzmann, A Hawlitschka… - Toxins, 2022 - mdpi.com
… In addition, we analyzed the effect of a unilateral intrastriatal BoNT-… effect of intrastriatal
BoNT-A in hemi-PD rats with respect to the reduction of apomorphine-induced rotational behavior

Exploring the Central Mechanisms of Botulinum Toxin in Parkinson's Disease: A Systematic Review from Animal Models to Human Evidence

C Cutrona, F Marchet, M Costanzo, MI De Bartolo… - Toxins, 2023 - mdpi.com
… that focused on the effect of intrastriatal BoNT injections on the … PD rats had an increased
depressive-like behaviour that … and depressive behaviour before and after the intrastriatal BoNT …

Distribution of Cleaved SNAP-25 in the Rat Brain, following Unilateral Injection of Botulinum Neurotoxin-A into the Striatum

F Schümann, O Schmitt, A Wree… - International Journal of …, 2023 - mdpi.com
… Here, we aimed to determine the spread of intrastriatally … with the claim to prevent side
effects in other brain areas, in this … reporting reduced anxiety behavior after intrastriatal BoNT-A …

Rivastigmine ameliorates botulinum-induced hippocampal damage and spatial memory impairment in male rats

K Mehri, ZZ Oskuye, E Nassireslami, E Karami… - Neurotoxicology, 2023 - Elsevier
… regarding the effects of different doses of botulinum toxin on the … of the administration of
botulinum toxin and rivastigmine on … Furthermore, the results of the MWM behavioral test in this …

[PDF][PDF] Supplementary Materials: Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's …

V Antipova, C Holzmann, A Hawlitschka, M Witt… - researchgate.net
Behavioral and neurochemical effects of chronic L-DOPA treatment on nonmotor sequelae
in the hemiparkinsonian rat… antidepressant-like effects in a unilateral rat model of Parkinson’s …