Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway

M Xiang, T Liu, C Tian, K Ma, J Gou, R Huang… - Pharmacological …, 2022 - Elsevier
possible to ease LF via enhancing DC immunosuppression. To further explore this, we
detected the role of KD in LF therapy … The results suggested that KD exhibited attenuated effects

[HTML][HTML] Advances in the therapeutic application and pharmacological properties of kinsenoside against inflammation and oxidative stress-induced disorders

L Lu, Y Xiong, Z Lin, X Chu, AC Panayi, Y Hu… - Frontiers in …, 2022 - frontiersin.org
Dendritic cells (DCs), a type of highly efficient antigen-… cells are activated to induce autoimmune
hepatitis (AIH) in mice … by KD in the model of autoimmune hepatitis, while it was reported …

Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway

Y Deng, Q Xu, T Chen, J Ming, Y Wang, L Mao, J Zhou… - Phytomedicine, 2022 - Elsevier
… and nontoxic properties, KD has the potential to be a novel and effective drug to treat NASH.
… attenuated autoimmune hepatitis or liver fibro-inflammation by suppressing dendritic cells …

Therapeutic Effect of Costunolide in Autoimmune Hepatitis: Network Pharmacology and Experimental Validation

Z Huang, S Nie, S Wang, H Wang, J Gong, W Yan… - Pharmaceuticals, 2023 - mdpi.com
… to the standard immunosuppressive therapy of steroids and … 200 potential targets of
costunolide. Using the search word “… , PI3K-AKT pathway is activated in hepatocytes and dendritic

Roles and therapeutic targeting of dendritic cells in liver fibrosis

B Wang, L Yang, X Yuan, Y Zhang - Journal of Drug Targeting, 2024 - Taylor & Francis
… in autoimmune liver diseases like autoimmune hepatitis [Citation… This study found that
kinsenoside is able to inhibit DCs … the gene or drug level, the possible side effects should be fully …

Kinsenoside alleviates alcoholic liver injury by reducing oxidative stress, inhibiting endoplasmic reticulum stress, and regulating AMPK-dependent autophagy

L Gao, X Chen, Z Fu, J Yin, Y Wang, W Sun… - Frontiers in …, 2022 - frontiersin.org
… , the liver protective effects and potential mechanisms of KD in alcoholic liver disease (ALD) …
This study aimed to investigate the liver protective activity and potential mechanisms of KD …

[HTML][HTML] Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

F Zhou, J Mei, X Han, H Li, S Yang, M Wang… - … Pharmaceutica Sinica B, 2019 - Elsevier
… found to be a potential immunosuppressive drug which could disrupt dendritic cells (DC)-induced
cross-priming of CD8 + T cell responses in treatment of autoimmune hepatitis (AIH) 49 …

Kinsenoside alleviates 17α-ethinylestradiol-induced cholestatic liver injury in rats by inhibiting inflammatory responses and regulating FXR-mediated bile acid …

J Ming, Q Xu, L Gao, Y Deng, J Yin, Q Zhou, Q Tong… - Pharmaceuticals, 2021 - mdpi.com
… It has been demonstrated that Kinsenoside (KD, the … that has multiple pharmacological effects
on anti-hyperlipidemia [26… the effect of KD against EIC, and further understand the potential

Liver DCs in health and disease

TH Wirtz, EF Brandt, ML Berres - International review of cell and molecular …, 2019 - Elsevier
… Hepatic dendritic cells represent a unique and multifaceted subset of antigen-presenting …
kinsenoside as a potential immunosuppressive drug for autoimmune hepatitis: Kinsenoside is a …

Traditional Chinese medicines and natural products targeting immune cells in the treatment of metabolic-related fatty liver disease

Z Li, H Ouyang, J Zhu - Frontiers in Pharmacology, 2023 - frontiersin.org
… some may interact with medications or have potential side effects. 4.5 Target dendritic
cells … , several other drugs have demonstrated potential therapeutic effects on MAFLD by …