Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

D Malhan, M Yalçin, B Schoenrock, D Blottner… - npj …, 2023 - nature.com
… To assess circadian gene expression in WT mice and the impact of circadian clock alterations
in mouse skeletal muscle, we analysed time-course microarray datasets derived from WT …

Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space

SM Cadena, Y Zhang, J Fang, S Brachat, P Kuss… - Scientific reports, 2019 - nature.com
… between spaceflightskeletal muscles lose mass in space, we performed RNAseq analysis
on the soleus and gastrocnemius to ascertain differences in gene expression profiles in mice

[HTML][HTML] Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice

G Vitry, R Finch, G Mcstay, A Behesti, S Déjean… - Iscience, 2022 - cell.com
… such as DNA repair, autophagy, and translation in the muscle. Our results … gene expression
in the liver and muscle atrophy gene expression are two paired events during spaceflight, for …

Factors mediating spaceflight-induced skeletal muscle atrophy

PHU Lee, M Chung, Z Ren… - American Journal of …, 2022 - journals.physiology.org
… ), and IL-10 mRNA expression in skeletal muscle after 7-day bed … hindlimb immobilization
in mice lead to skeletal muscle atrophy … of mitochondrion-associated gene expression (157). …

Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment

R Okada, S Fujita, R Suzuki, T Hayashi, H Tsubouchi… - Scientific reports, 2021 - nature.com
… These results suggested that gravitational change could affect the muscle’s gene expression
profile in mice under spaceflight for 35 days rather than other events, such as space …

Differential Gene Expression Analysis of Rodents Exposed to Long-Term Space Flight and Insights into Physiological Effects

J Oribello - 2021 - scholarworks.sjsu.edu
… In this project, differential gene expression analysis was … into the physiological effect of
space flight on skeletal muscle and … After adaptor removal, reads were mapped to the mouse

Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength

RC Smith, MS Cramer, PJ Mitchell, J Lucchesi… - PloS one, 2020 - journals.plos.org
… of prolonged spaceflight are known to result in skeletal muscle … -term microgravity-induced
muscle atrophy expected in mice … modulated gene expression in skeletal muscle concomitant …

Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight

M Henrich, P Ha, Y Wang, K Ting, L Stodieck, C Soo… - Skeletal muscle, 2022 - Springer
… Most interest has been paid to the transcriptomic effects at the level of differential gene
expression (DGE). Recent transcriptome analyses of skeletal muscle in mice [19,20,21] have …

Genetic diversity modulates the physical and transcriptomic response of skeletal muscle to simulated microgravity in male mice

Y Zeineddine, MA Friedman, EG Buettmann… - npj …, 2023 - nature.com
… in-depth analysis of genetic expression has been performed. Here… A primary risk of spaceflight
is skeletal muscle deconditioning… mouse strain and SM was found for both skeletal muscle

Mammalian and invertebrate models as complementary tools for gaining mechanistic insight on muscle responses to spaceflight

T Cahill, H Cope, JJ Bass, EG Overbey… - International Journal of …, 2021 - mdpi.com
… (EDL) in mice that underwent 37 days of spaceflight. Results … studying the skeletal muscle
response to spaceflight. These … on muscle gene regulation under spaceflight conditions. To …