[HTML][HTML] Effectiveness and safety of afatinib, gefitinib, and erlotinib for treatment-naïve elderly patients with epidermal growth factor receptor-mutated advanced non …

LJ Hung, PC Hsu, CT Yang, CHS Kuo… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
… , we aimed to describe the effectiveness and safety of afatinib, gefitinib, and erlotinib for …
a first-line treatment than gefitinib or erlotinib for elderly patients with EGFR-mutated advanced

Efficacy of first-line treatments in the elderly and non-elderly patients with advanced epidermal growth factor receptor mutated, non-small cell lung cancer: a network …

Z Xu, C Liu, Y Zhu, Z Zou, T Xie, P Xing, L Wang, J Li - BMC cancer, 2022 - Springer
elderly and non-elderly EGFR-mutated NSCLC patients by comparing the efficacy of diverse
first-line treatments with gefitinib, erlotinib… , for elderly and non-elderly patients harboring …

First-line treatment of metastatic non-small cell lung cancer in the elderly

T Losanno, C Gridelli - Current Oncology Reports, 2021 - Springer
Erlotinib demonstrated a better PFS compared with first-line standard chemotherapy in the
trials OPTIMAL [21] (13.1 months for erlotinib … the efficacy of osimertinib in 36 elderly patients

Low-dose erlotinib treatment in elderly or frail patients with EGFR mutation–positive nonsmall cell lung cancer: A multicenter phase 2 trial

S Miyamoto, K Azuma, H Ishii, A Bessho… - JAMA …, 2020 - jamanetwork.com
First-line gefitinib for patients with advanced nonsmall-cell … low-dose erlotinib would be safe
and effective in elderly or frail … -dose erlotinib was associated with efficacy and safety in frail …

… of First-Line EGFR-Tyrosine Kinase Inhibitor Treatment in Older Adults Including Poor Performance Status Patients with EGFR-Mutated Non-Small-Cell Lung Cancer

CY Chang, CY Chen, SC Chang, YC Lai… - Cancer Management …, 2021 - Taylor & Francis
… For example, most of the older patients and patients with poor PS included in the current
study were treated with gefitinib or erlotinib. In addition, the sample size was relatively small, …

Real world data of efficacy and safety of erlotinib as first-line TKI treatment in EGFR mutation-positive advanced non-small cell lung cancer: Results from the EGFR …

T Payen, J Trédaniel, L Moreau, S Larivé… - … Medicine and Research, 2021 - Elsevier
… of non-small cell lung cancer (NSCLC) patients with EGFR-activating mutations. Using a
cohort of unselected patients treated with erlotinib, we sought to further describe patient and …

Efficacy and safety of anlotinib in advanced non-small cell lung cancer: a real-world study

K Zhang, X Ma, H Gao, H Wang, H Qin… - Cancer management …, 2020 - Taylor & Francis
… ramucirumab/bevacizumab combined with erlotinib could improve PFS compared with erlotinib
treatment alone as the first-line treatment in advanced patients with EGFR-mutant NSCLC…

Efficacy of erlotinib and its effects on the quality of life of older patients with epidermal growth factor receptor‐mutant nonsmall cell lung cancer: A prospective …

Y Tsubata, T Masuda, K Hamai… - Geriatrics & …, 2021 - Wiley Online Library
… In conclusion, first-line erlotinib shows sufficient efficacy in older patients with EGFR-mutant
NSCLC, even when started at 100 mg/day. The results of the present study also suggest the …

Second-line erlotinib after failure of pemetrexed-containing chemotherapy in advanced non-small cell lung cancer (NSCLC): Real-world effectiveness, safety and …

P Germonpré, T Van den Wyngaert - Plos one, 2019 - journals.plos.org
… non-squamous NSCLC treated with erlotinib specifically after failure of first-line
pemetrexed-containing chemotherapy. We assessed the effectiveness, safety and tolerability of …

Effectiveness and safety of EGFR-TKI rechallenge treatment in elderly patients with advanced non-small-cell lung cancer harboring drug-sensitive EGFR mutations

Y Yamada, H Imai, T Sugiyama, H Minemura… - Medicina, 2021 - mdpi.com
effectiveness and safety profiles of EGFR-TKI rechallenge after first-line EGFR-TKI treatment
in elderly patients … dose change for erlotinib, and the dose reduction in the elderly of smaller …