Chemo-immunotherapy combination after PD-1 inhibitor failure improves clinical outcomes in metastatic melanoma patients

…, H Zhang, Y Li, AB Kumar, J Failing… - Melanoma …, 2020 - journals.lww.com
One of the barriers in developing efficacious salvage … CIT combination reported in NSCLC
studies [ 12 , 18 ], we have employed the addition of cytotoxic chemotherapy to ongoing PD-1

Efficacy and safety of antiPD1/PD‐L1 in combination with chemotherapy or not as first‐line treatment for advanced non‐small cell lung cancer: a systematic review …

L Wang, Y Yang, J Yu, S Zhang, X Li, X Wu… - Thoracic …, 2022 - Wiley Online Library
… into the form of lnHR and standard error of lnHR (selnHR). As … of 185 records were reviewed
for full-text assessment after … that the combination of Pembro/Atez and Chemo are preferred …

[HTML][HTML] Anti-PD-1 therapy plus chemotherapy and/or bevacizumab as second line or later treatment for patients with advanced non-small cell lung cancer

F Zhang, D Huang, T Li, S Zhang, J Wang… - Journal of …, 2020 - ncbi.nlm.nih.gov
… the efficacy of combined therapy of PD-1 inhibitor with … A total of 50 (90.9%) patients in this
study have failed after … plus beva and 75% (3/4) in anti-PD-1 plus chemo/beva. The DCR was …

[HTML][HTML] Efficacy and safety of PD-1 inhibitors combined with chemotherapy as first-line therapy for advanced esophageal cancer: a systematic review and network …

ZC Li, YT Sun, MY Lai, YX Zhou, MZ Qiu - International …, 2022 - Elsevier
After rigorous screening, 5 studies involving a total of 3,163PD-1 inhibitors plus
chemotherapy combinations, tori-chemo … However, we failed to find similar results in our analysis. …

Platinum-based chemotherapy in combination with PD-1/PD-L1 inhibitors: preclinical and clinical studies and mechanism of action

Y Xue, S Gao, J Gou, T Yin, H He, Y Wang… - Expert opinion on …, 2021 - Taylor & Francis
… surgery, radiotherapy and chemotherapy [Citation4]. However… KEYNOTE-021 was first
conducted to evaluate the efficacy of … undergone systemic treatment failure. Toripalimab displayed …

[HTML][HTML] A combination of PD1/PD‑L1 inhibitors: The prospect of overcoming the weakness of tumor immunotherapy

X Kong, P Lu, C Liu, Y Guo… - Molecular …, 2021 - spandidos-publications.com
… Tim-3 (+) PD-1 (+) TILs is a severe failure phenotype, which does not proliferate to produce
… with chemotherapy alone (93,94). Anti-PD-1 therapy enhances the efficacy of radiotherapy in …

[HTML][HTML] Chemotherapy after immune checkpoint inhibitor failure in metastatic melanoma: a retrospective multicentre analysis

SM Goldinger, K Buder-Bakhaya, SN Lo… - European Journal of …, 2022 - Elsevier
efficacy when used in combination with immunotherapy in lung cancer. Whether chemotherapy
after checkpoint inhibitor failure … the efficacy and safety of various chemotherapy regimes …

Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma …

Y Nakamura, K Namikawa, S Yoshikawa, Y Kiniwa… - ESMO open, 2021 - Elsevier
… As the selection of second-line salvage therapy after failure of PD1 may impact survival,
Kaplan… Four studies have tested the efficacy of PD1 plus radiotherapy, including a study recently …

Anti-PD-1 and novel combinations in the treatment of melanoma—an update

FF Gellrich, M Schmitz, S Beissert, F Meier - Journal of clinical medicine, 2020 - mdpi.com
… results in terms of both efficacy and toxicity [4,15]. KEYNOTE-… half of patients with MBM fail
to respond to systemic therapy. … -week interval to radiotherapy were analyzed [49]. The best …

Building on the anti-PD1/PD-L1 backbone: combination immunotherapy for cancer

AH Ingles Garces, L Au, R Mason… - Expert Opinion on …, 2019 - Taylor & Francis
… in 2018 evaluating the efficacy of the combination of immune-… to chemotherapy alone;
however, two further phase 3 studies … with NSCLC failed to confirm the original phase 2 findings …