Efficacy of niclosamide vs placebo in SARS-CoV-2 respiratory viral clearance, viral shedding, and duration of symptoms among patients with mild to moderate COVID …
DM Cairns, D Dulko, JK Griffiths, Y Golan… - JAMA network …, 2022 - jamanetwork.com
Importance Oral anthelmintic niclosamide has potent in vitro antiviral activity against SARS-
CoV-2. Repurposed niclosamide could be a safe and efficacious COVID-19 therapy.
Objective To investigate whether niclosamide decreased SARS-CoV-2 shedding and
duration of symptoms among patients with mild to moderate COVID-19. Design, Setting, and
Participants This randomized, placebo-controlled clinical trial enrolled individuals testing
positive for SARS-CoV-2 by polymerase chain reaction with mild to moderate symptoms of …
CoV-2. Repurposed niclosamide could be a safe and efficacious COVID-19 therapy.
Objective To investigate whether niclosamide decreased SARS-CoV-2 shedding and
duration of symptoms among patients with mild to moderate COVID-19. Design, Setting, and
Participants This randomized, placebo-controlled clinical trial enrolled individuals testing
positive for SARS-CoV-2 by polymerase chain reaction with mild to moderate symptoms of …
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