Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

SY Loo, LP Toh, WH Xie, E Pathak, W Tan, S Ma… - Science …, 2021 - science.org
… expounded on the role of lipogenesis via fatty acid synthase to … mesenchymal cell phenotype
through EMT confers resistance … advantage was observed in the mesenchymal cancer cell

Prevention of breast cancer by dietary polyphenols—role of cancer stem cells

HF Gu, XY Mao, M Du - Critical reviews in food science and …, 2020 - Taylor & Francis
… , key lipogenic genes were upregulated in ductal carcinoma … conducted in cultured cells and
in rodents, where high doses of … of stem-like cells which are the sources of all differentiated …

[HTML][HTML] Mutant p53 gain-of-function: role in cancer development, progression, and therapeutic approaches

E Alvarado-Ortiz, KG de la Cruz-López… - Frontiers in cell and …, 2021 - frontiersin.org
… not only abolish tumor suppressor capacities but confer various … In particular, the increased
lipogenic activity through the … , where stem-like cells are positioned at the top and are …

Acetyl-CoA carboxylase 1-dependent lipogenesis drives breast cancer progression

K Tan, T Owen, HP McEwen, P Simpson, AJ Hoy… - bioRxiv, 2023 - biorxiv.org
… in normal breast and high expression during breast cancersurvival, which was driven by
a decrease in cancer cell … upregulated in ductal carcinoma in situ (DCIS). DCIS is the most …

[HTML][HTML] Ovarian cancer—why lipids matter

G Zhao, H Cardenas, D Matei - Cancers, 2019 - mdpi.com
Increased lipogenesis dependent on the fatty acid … fatty acids and conferred bioenergetic
advantage necessary to … models and compared cells isolated from the primary tumor site versus …

Adaptive phenotypic switching in breast cancer in response to matrix deprivation

A Sundararaman, S Kumar, A Rangarajan - Phenotypic Switching, 2020 - Elsevier
… provide cancer cells with a survival advantage that normal cells … in conferring survival properties
to matrix-deprived cells. For … /CD24 − stem-like cells and sensitizes MDA-MB-231 cells to …

[HTML][HTML] Metabolic escape routes of cancer stem cells and therapeutic opportunities

A Turdo, G Porcelli, C D'Accardo, S Di Franco… - Cancers, 2020 - mdpi.com
Cells showing stem-like features strongly rely on … -positive breast cancers are associated
with de novo lipogenesis [… of releasing the drug directly at the tumor site. For instance, gold …

[HTML][HTML] Regulation of metabolic plasticity in cancer stem cells and implications in cancer therapy

S Papadaki, A Magklara - Cancers, 2022 - mdpi.com
… A main advantage of aerobic glycolysis is the rapid production of … novo lipogenesis and,
subsequently, in the inhibition of cell proliferation… of breast cancer cells into a stem-like state [94]. …

[HTML][HTML] Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells

H Li, Z Feng, ML He - Theranostics, 2020 - ncbi.nlm.nih.gov
… , FAO is linked to stem-like properties with de novo fatty acid … lipogenesis, studies show GSC
requires more lipogenesis than … On the other hand, elevated peroxisome FAO benefits Tie2+ …

[HTML][HTML] Metabolic regulation of epithelial to mesenchymal transition: implications for endocrine cancer

D Bhattacharya, A Scimè - Frontiers in Endocrinology, 2019 - frontiersin.org
… the dislocation of cancer cells from the primary tumor site with … a survival benefit against
anoikis, which is a type of cell … , de novo lipogenesis is augmented in many cancers, but little is …