[HTML][HTML] SRC kinase-mediated signaling pathways and targeted therapies in breast cancer

J Luo, H Zou, Y Guo, T Tong, L Ye, C Zhu, L Deng… - Breast Cancer …, 2022 - Springer
… This study highlighted that increased SRC activities were … Cancer stem-like cells (CSCs), a
subpopulation of cancer … signatures to select patients with clinical benefits from Dasatinib [123]…

[HTML][HTML] The metabolic mechanisms of breast cancer metastasis

L Wang, S Zhang, X Wang - Frontiers in Oncology, 2021 - frontiersin.org
… (SREBP)-1, a lipogenic transcription factor, can regulate … to the primary tumor site and breast
cancer subtype. Not only pro-… metastatic growth of breast cancer stem-like cells by activating …

Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer

D Jia, JH Park, H Kaur, KH Jung, S Yang… - … Journal of Cancer, 2021 - nature.com
… , increased mitochondrial mass and activity can confer stem-like traits on cancer cells and …
TGF-β treatment decreases the master lipogenic regulator carbohydrate-responsive element-…

[HTML][HTML] The lipid metabolic landscape of cancers and new therapeutic perspectives

W Wang, L Bai, W Li, J Cui - Frontiers in oncology, 2020 - frontiersin.org
… with an increase in the activity of key lipogenic enzymes. The … analysis showed that ovarian
cancer stem-like cells (CSCs) (… Statins are proven to benefit lung cancer patients receiving …

Phytocompounds targeting metabolic reprogramming in cancer: an assessment of role, mechanisms, pathways, and therapeutic relevance

A Khan, S Siddiqui, SA Husain… - Journal of Agricultural …, 2021 - ACS Publications
… and confers a variety of benefits, including the promotion of … apoptosis in the cancer stem-like
cells through suppression of FA … lipogenic enzymes FASN, ACC, ACLY, and lipogenesis

[HTML][HTML] Augmented CPT1A expression is associated with proliferation and colony formation during Barrett's tumorigenesis

JN Bernard, V Chinnaiyan, T Andl, GF Le Bras… - International Journal of …, 2022 - mdpi.com
… diet or synthesized endogenously via de novo lipogenesis [42]. It … lines, OE33 and FLO1
showed significant growth advantages at … -mediated FAO in the acquisition of stem-like features. …

[HTML][HTML] Cancer plasticity: the role of mRNA translation

LJ Lee, D Papadopoli, M Jewer, S Del Rincon… - Trends in cancer, 2021 - cell.com
… synthesis and increased selective translation of mRNAs essential for adaptation and survival,
including … , and the epithelial and mesenchymal components of uterine carcinosarcoma [ …

The metabolism of cancer cells during metastasis

G Bergers, SM Fendt - Nature Reviews Cancer, 2021 - nature.com
… shown to confer a selective advantage to cancer cells both at … Mechanistically, FASN-mediated
de novo lipogenesis … enzymes were elevated in MDA-MB-231 breast cancer cells with …

[HTML][HTML] The role of CD36 in cancer progression and its value as a therapeutic target

WW Feng, HT Zuppe, M Kurokawa - Cells, 2023 - mdpi.com
… of a stem-like phenotype in pancreatic neuroendocrine tumors [… cells confers metabolic
plasticity and allows them to survivelipogenesis is the predominant source of FAs for cancer cells

[HTML][HTML] SP and KLF transcription factors in cancer metabolism

EJ Orzechowska-Licari, JF LaComb… - International Journal of …, 2022 - mdpi.com
… metabolism in vitro, and increased survival in vivo. Both genetic … In breast cancer, cancer
stem-like cells (CSC) can alter … and ACC1 expression to increase lipogenesis and lipid droplet …