Assessment of kidney transplant suitability for patients with prior cancers: is it time for a rethink?

WH Lim, E Au, A Krishnan, G Wong - Transplant International, 2019 - Wiley Online Library
… a proportion of patients with end-stage kidney disease (ESKD)… in determining the transplant
eligibility of patients with prior … for the Caring for Australasians with Renal Impairment (CARI) …

[HTML][HTML] Improving cancer care for patients with CKD: the need for changes in clinical trials

B Sprangers, MA Perazella, SM Lichtman… - Kidney International …, 2022 - Elsevier
… , we must rethink the exclusion of cancer patients with an … renal insufficiency’ cohort could
be used to include patients with … eligibility criteria for patients with CKD in clinical cancer trials

Assessment of eligibility criteria in renal cell carcinoma trials evaluating systemic therapy

DV Castro, SR Prajapati, MI Feng, EH Chan… - BJU …, 2024 - Wiley Online Library
Phase I trials excluded the greatest proportion of patients … ), and Phase III trials excluded the
greatest proportion of patients … future studies need to reassess barriers of enrolment such as …

Kidney disease trials for the 21st century: innovations in design and conduct

WG Herrington, N Staplin, R Haynes - Nature Reviews Nephrology, 2020 - nature.com
… on clinical outcomes in renal disease may occur because … is increased by designing trials
with simple eligibility criteria and … time for patients, investigators and clinicians to reconsider

[HTML][HTML] Rethinking chronic kidney disease in the aging population

G Alfano, R Perrone, F Fontana, G Ligabue… - Life, 2022 - mdpi.com
… /year people if mortality due to acute renal failure was included. … patients with stage IIIa of
CKD have a mortality risk lower than … the eligibility for kidney transplantation for older patients

Time to rethink the current paradigm for assessing kidney function in drug development and beyond

A Sharma, V Sahasrabudhe, L Musib… - Clinical …, 2022 - Wiley Online Library
patients in this study were in an early post-transplant phase … 2 (upper limit of moderate renal
impairment) should receive the … There are no agency-specific requirements for methodology …

Modernizing clinical trial eligibility criteria: recommendations of the ASCO-Friends of Cancer Research laboratory reference ranges and testing intervals work group

AI Spira, MD Stewart, S Jones, E Chang, A Fielding… - Clinical Cancer …, 2021 - AACR
… test eligibility requirements and testing intervals in clinical trials. … over time and trial phase
in laboratory test requirements, … suggests that enrolling patients with renal dysfunction may not …

[HTML][HTML] … antithymocyte globulin induction in kidney transplantation (RETHINK): an analysis of the North American Pediatric Renal Trials and Collaborative Studies  …

IF Ashoor, K Martz, S Galbiati, RA Beyl… - Transplantation …, 2020 - journals.lww.com
… Cause of end-stage renal disease was attributed to congenital anomalies of the kidney and
… Of note, our eligible subject number was significantly lower than the total registry count for …

Timing of kidney support therapy in acute kidney injury: what are we waiting for?

J Bouchard, RL Mehta - American Journal of Kidney Diseases, 2022 - Elsevier
… at KDIGO stage 2 or within 24 hours after acute renal failure of … The time from eligibility to
KST initiation was 6 hours in the … We must reconsider our approach to studying the timing of KST…

[HTML][HTML] The current and future landscape of dialysis

J Himmelfarb, R Vanholder, R Mehrotra… - Nature Reviews …, 2020 - nature.com
… for end-stage renal disease (now known as kidney failure), … of stringent patient selection for
dialysis eligibility in most HICs; … Hence, a pressing need exists to rethink the current economic …