Development of a broad-spectrum antiserum against cobra venoms using recombinant three-finger toxins

BS Liu, BR Jiang, KC Hu, CH Liu, WC Hsieh, MH Lin… - Toxins, 2021 - mdpi.com
… chain α-neurotoxins (P60770), and cardiotoxin A3 (P60301) to … Taiwan cobra (Naja atra),
and the Thai spitting cobra (Naja … other CTX analogous in the venoms of cobra snake species. It …

Effects of Cobra Cardiotoxins on Intracellular Calcium and the Contracture of Rat Cardiomyocytes Depend on Their Structural Types

AS Averin, AV Berezhnov, OY Pimenov… - International Journal of …, 2023 - mdpi.com
… Depending on the structure of the N-terminal or the central … was observed for Naja oxiana
cobra cardiotoxin 2, which is of … ’ balanced salt solution (HBSS) with the following composition (…

Current insights in the mechanisms of cobra venom cytotoxins and their complexes in inducing toxicity: implications in antivenom therapy

B Kalita, YN Utkin, AK Mukherjee - Toxins, 2022 - mdpi.com
… across different Naja species; it was ~13% in Taiwanese N. … It should be noted that the
cardiotoxic activity of cobra venom, … Therefore, it remains to be elucidated as to whether or not the …

Variability in the spatial structure of the central loop in cobra cytotoxins revealed by X-ray analysis and molecular modeling

PV Dubovskii, KM Dubova, G Bourenkov, VG Starkov… - Toxins, 2022 - mdpi.com
… Here, we studied cytotoxin 13 from Naja naja cobra venom (… ray structure of cardiotoxin-like
basic protein A5 from Taiwan … NMR structures of homologues assists in elucidating functional …

Monitoring the disulfide bonds of folding isomers of synthetic CTX A3 polypeptide using MS-based technology

SY Huang, TY Wei, BS Liu, MH Lin, SK Chiang… - Toxins, 2019 - mdpi.com
… isomers during the folding reaction of synthetic cardiotoxin … of an investigation on the CTX
analog III, in which NMR … atra) was acquired from a snake farm (Tainan, Taiwan), and the CTX …

Cobra Venom Cytotoxins as a Tool for Probing Mechanisms of Mitochondrial Energetics and Understanding Mitochondrial Membrane Structure

ES Gasanoff, RK Dagda - Toxins, 2024 - mdpi.com
… IV, and ATP synthase and on elucidating physical–chemical as… CTII from Naja naja oxiana
and cardiotoxin VII4 from Naja … that cytotoxins from the Taiwan cobra rapidly colocalized to …

Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These …

PV Dubovskii, YN Utkin - Toxins, 2024 - mdpi.com
… of the structures of these forms in aqueous solution (Figure 4b, … neurotoxin and cardiotoxin
molecules from Naja sputatrix. The … Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 …

Local cytotoxic effects in cobra envenoming: a pilot study

JH Lin, WC Sung, HW Mu, DZ Hung - Toxins, 2022 - mdpi.com
… intervention in cases of cobra envenomation in Taiwan. … genus Naja (N.) in the family Elapidae,
also known as the cobra … asper envenomation have been elucidated more clearly in vitro …

Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1. 8

F Zhang, C Zhang, X Xu, Y Zhang, X Gong… - Journal of Biological …, 2019 - ASBMB
… from the venom of the Chinese cobra (Naja atra), as a potent … sequence identity with
cardiotoxin A5, cardiotoxin-like basic … of inhibition by washing with external solution (n = 5). F, …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
… and genes, and the elucidation of their dynamic crosstalk were just … of spitting cobras, perhaps
in synergism with the cardiotoxins or … : Naja atra of Taiwan, Naja kaouthia of Vietnam, Naja