A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer's and Parkinson's diseases

YP Singh, A Pandey, S Vishwakarma, G Modi - Molecular diversity, 2019 - Springer
… Therefore, the development of novel iron chelators as neuroprotective agents for the
treatment of neurodegeneration is an emerging trend. Several iron chelators including 8-…

The role of manganese dysregulation in neurological disease: emerging evidence

D Budinger, S Barral, AKS Soo, MA Kurian - The Lancet Neurology, 2021 - thelancet.com
… Moreover, manganese dyshomoeostasis is also implicated in Parkinson's disease and
other neurodegenerative conditions, such as Alzheimer's disease and Huntington's disease. …

Pesticides and Parkinson's disease: Current and future perspective

MS Islam, F Azim, H Saju, A Zargaran, M Shirzad… - Journal of Chemical …, 2021 - Elsevier
… Cell therapy is also an emerging and promising technology for disease modeling and drug
… have suggested a correlation of pesticides and Parkinson's disease (PD) while genetic and …

The understanding of Parkinson's disease through genetics and new therapies

O Uwishema, H Onyeaka, R Badri, AN Yücel… - Brain and …, 2022 - Wiley Online Library
… Nowadays, it is well known that the cause behind Parkinson's disease is mainly … ,
factors causing Parkinson's disease as well as future therapies for the cure of the diseases. …

[HTML][HTML] Emerging role of Sirtuin 2 in Parkinson's disease

Y Liu, Y Zhang, K Zhu, S Chi, C Wang… - Frontiers in aging …, 2020 - frontiersin.org
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases and is
characterized by the loss of dopaminergic (DA) neurons in the striatum and the aggregation of …

PARP inhibitors and Parkinson's disease

AL Olsen, MB Feany - New England Journal of Medicine, 2019 - Mass Medical Soc
Drug repurposing has emerged as a promising therapeutic strategy to reduce the costs and
safety failures associated with the development of new drugs. … Finally, there is emerging

[HTML][HTML] Historical perspective: models of Parkinson's disease

SJ Chia, EK Tan, YX Chao - International journal of molecular sciences, 2020 - mdpi.com
… Moreover, cell-based model has also emerged as a feasible disease model for PD. There
are distinct advantages and limitations of each group which determine the suitability of the …

Neuroprotective actions of glucagon-like peptide-1 (GLP-1) analogues in Alzheimer's and Parkinson's diseases

AF Batista, V Bodart-Santos, FG De Felice, ST Ferreira - CNS drugs, 2019 - Springer
… The current review provides a synthesis of emerging links between insulin resistance and
the pathogenesis of AD and PD and discusses the basis for investigation of antidiabetic agents…

[HTML][HTML] Modifiable risk and protective factors in disease development, progression and clinical subtypes of Parkinson's disease: What do prospective studies suggest …

D Belvisi, R Pellicciari, G Fabbrini, M Tinazzi… - … of disease, 2020 - Elsevier
… In conclusion, the findings that emerged from prospective studies designed to investigate
the dietary intake of calories, carbohydrates, proteins, and cholesterol excluded a strong …

[HTML][HTML] Role of exosomes in the pathogenesis of inflammation in Parkinson's disease

KL Li, HY Huang, H Ren, XL Yang - Neural Regeneration …, 2022 - journals.lww.com
Inflammatory responses, including glial cell activation and peripheral immune cell infiltration,
are involved in the pathogenesis of Parkinson’s disease (PD). These inflammatory …