Targeting the androgen receptor and overcoming resistance in prostate cancer
… The extent to which AR-V7 (or AR-FL) is driving ABI/ENZ resistance will not be clear until
effective inhibitors are available. In addition to APA, there are several other new agents in …
effective inhibitors are available. In addition to APA, there are several other new agents in …
Androgen receptor-dependent mechanisms mediating drug resistance in prostate cancer
M Ehsani, FO David, A Baniahmad - Cancers, 2021 - mdpi.com
… mechanisms leading to therapy resistance against ADT and antagonists and AR bypass
mechanisms as … A new development to identify AR antagonists that target AR NTD is another …
mechanisms as … A new development to identify AR antagonists that target AR NTD is another …
Perspectives on the current and emerging chemical androgen receptor antagonists for the treatment of prostate cancer
AE Dellis, AG Papatsoris - Expert Opinion on Pharmacotherapy, 2019 - Taylor & Francis
… mechanisms behind castration resistance has led to the approval of novel oral androgen
receptor (AR) antagonists, such … current and emerging AR antagonists for the treatment of PCa. …
receptor (AR) antagonists, such … current and emerging AR antagonists for the treatment of PCa. …
[HTML][HTML] Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer
CM Armstrong, AC Gao - American Journal of Clinical and …, 2021 - ncbi.nlm.nih.gov
… new knowledge and explore better treatments for cancer. … androgen receptor mutants
obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer…
obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer…
Mechanisms of enzalutamide resistance in castration‐resistant prostate cancer and therapeutic strategies to overcome it
Y Wang, J Chen, Z Wu, W Ding, S Gao… - British journal of …, 2021 - Wiley Online Library
… androgen receptor antagonist approved by the Food and Drug Administration to treat
patients with castration-resistant prostate cancer. … In conclusion, these emerging mechanisms …
patients with castration-resistant prostate cancer. … In conclusion, these emerging mechanisms …
Resistance to second-generation androgen receptor antagonists in prostate cancer
KT Schmidt, ADR Huitema, CH Chau… - Nature Reviews …, 2021 - nature.com
… The introduction of second-generation androgen receptor antagonists (SG-ARAs) has
greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious …
greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious …
Molecular mechanisms related to hormone inhibition resistance in prostate cancer
V Mollica, V Di Nunno, A Cimadamore… - Cells, 2019 - mdpi.com
… New anti-androgens are able to improve hormone depletion … mechanism of resistance to
androgen receptor inhibitors can … receptor pathway through a different hormone receptor like …
androgen receptor inhibitors can … receptor pathway through a different hormone receptor like …
Recent discoveries in the androgen receptor pathway in castration-resistant prostate cancer
D Obinata, MG Lawrence, K Takayama, N Choo… - Frontiers in …, 2020 - frontiersin.org
… new tools to validate and prioritize candidate treatments for clinical trials. In this review, we
examine mechanisms of castration-resistance involving the AR and collaborating TFs, new …
examine mechanisms of castration-resistance involving the AR and collaborating TFs, new …
Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment
… This suggests that development of new therapies that can … characteristic mechanisms of
enzalutamide-resistance, such … at inhibiting growth of enzalutamide-resistant prostate cancer …
enzalutamide-resistance, such … at inhibiting growth of enzalutamide-resistant prostate cancer …
[HTML][HTML] Metabolic reprogramming as an emerging mechanism of resistance to endocrine therapies in prostate cancer
P Chetta, G Zadra - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
… Prostate cancer (PCa) is the second leading cause of cancer-related death in the US. Androgen
receptor (AR) … -generation inhibitors of AR signaling in the metastatic setting, resistance …
receptor (AR) … -generation inhibitors of AR signaling in the metastatic setting, resistance …