… The extent to which AR-V7 (or AR-FL) is driving ABI/ENZ resistance will not be clear until
effective inhibitors are available. In addition to APA, there are several other new agents in …

… mechanisms leading to therapy resistance against ADT and antagonists and AR bypass
mechanisms as … A new development to identify AR antagonists that target AR NTD is another …

… mechanisms behind castration resistance has led to the approval of novel oral androgen
receptor (AR) antagonists, such … current and emerging AR antagonists for the treatment of PCa. …

… new knowledge and explore better treatments for cancer. … androgen receptor mutants
obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer…

… androgen receptor antagonist approved by the Food and Drug Administration to treat
patients with castration-resistant prostate cancer. … In conclusion, these emerging mechanisms …

… The introduction of second-generation androgen receptor antagonists (SG-ARAs) has
greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious …

… New anti-androgens are able to improve hormone depletion … mechanism of resistance to
androgen receptor inhibitors can … receptor pathway through a different hormone receptor like …

… new tools to validate and prioritize candidate treatments for clinical trials. In this review, we
examine mechanisms of castration-resistance involving the AR and collaborating TFs, new …

… This suggests that development of new therapies that can … characteristic mechanisms of
enzalutamide-resistance, such … at inhibiting growth of enzalutamide-resistant prostate cancer …

… Prostate cancer (PCa) is the second leading cause of cancer-related death in the US. Androgen
receptor (AR) … -generation inhibitors of AR signaling in the metastatic setting, resistance …