[HTML][HTML] The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
J Zhou, Q Yi, L Tang - Journal of Experimental & Clinical Cancer Research, 2019 - Springer
… Furthermore, we emphasize that nuclear FAK also has an important role in the study of
cancer, which is positively related to the occurrence and development of tumors. …
cancer, which is positively related to the occurrence and development of tumors. …
[HTML][HTML] Targeting focal adhesion kinase in cancer cells and the tumor microenvironment
JM Murphy, YAR Rodriguez, K Jeong… - … & molecular medicine, 2020 - nature.com
… not investigate the role of nuclear FAK in ovarian cancer or any … analyses of human cancers
have provided new insights into … better understand FAK’s role in the nucleus of cancer cells. …
have provided new insights into … better understand FAK’s role in the nucleus of cancer cells. …
Focal adhesion dynamics in cellular function and disease
YG Mishra, B Manavathi - Cellular signalling, 2021 - Elsevier
… the cytoskeleton of the cell and the extra cellular matrix (ECM), the cell-ECM adhesions with
integrins at their core, play a major role in cell signalling to direct mechanotransduction, cell …
integrins at their core, play a major role in cell signalling to direct mechanotransduction, cell …
[HTML][HTML] Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
DC Rigiracciolo, MF Santolla, R Lappano… - … & Clinical Cancer …, 2019 - Springer
… STAT3 transcription factor signaling inhibitor STA21 and Focal Adhesion Kinase selective
inhibitor VS-4718 were bought from Santa Cruz Biotechnology (DBA, Milan, Italy). All the …
inhibitor VS-4718 were bought from Santa Cruz Biotechnology (DBA, Milan, Italy). All the …
Progress in the development of small molecular inhibitors of focal adhesion kinase (FAK)
Y Lu, H Sun - Journal of Medicinal Chemistry, 2020 - ACS Publications
… Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion… activities and scaffolding functions. Overexpression of FAK …
essential role in cancer cell adhesion… activities and scaffolding functions. Overexpression of FAK …
Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer
H Zhang, A Schaefer, Y Wang, RG Hodge, DR Blake… - Cancer discovery, 2020 - AACR
… enhancing actin rearrangements and focal adhesion formation. Furthermore, we demonstrate
that Cdh1 loss and RHOA Y42C induce DGC via activation of focal adhesion kinase (FAK), …
that Cdh1 loss and RHOA Y42C induce DGC via activation of focal adhesion kinase (FAK), …
Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer
DE Gerber, DR Camidge, D Morgensztern, J Cetnar… - Lung Cancer, 2020 - Elsevier
… Focal adhesion kinase (FAK) may represent a new therapeutic target in KRAS mutant lung
cancer. … non-receptor tyrosine kinase that has roles in cellular adhesion, migration, and stem …
cancer. … non-receptor tyrosine kinase that has roles in cellular adhesion, migration, and stem …
[HTML][HTML] FAK structure and regulation by membrane interactions and force in focal adhesions
P Tapial Martínez, P López Navajas, D Lietha - Biomolecules, 2020 - mdpi.com
… kinase with key roles in the regulation of cell adhesion migration, proliferation and survival.
In cancer FAK … Focal adhesion kinase (FAK) was discovered almost three decades ago as a …
In cancer FAK … Focal adhesion kinase (FAK) was discovered almost three decades ago as a …
ORAI2 promotes gastric cancer tumorigenicity and metastasis through PI3K/Akt signaling and MAPK-dependent focal adhesion disassembly
… promoted focal adhesion disassembly at rear-edge of the cell. … role in the tumorigenicity
and metastasis of gastric cancer. … Focal adhesion kinase (FAK), a nonreceptor protein tyrosine …
and metastasis of gastric cancer. … Focal adhesion kinase (FAK), a nonreceptor protein tyrosine …
[HTML][HTML] Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells
CA Berdan, R Ho, HS Lehtola, M To, X Hu… - Cell chemical …, 2019 - cell.com
… of focal adhesion kinase 1 (FAK1), leading to impairment of FAK1-dependent signaling
pathways and breast cancer cell … by members of a large family of anti-cancer natural products. …
pathways and breast cancer cell … by members of a large family of anti-cancer natural products. …