Endocannabinoid system in hepatic glucose metabolism, fatty liver disease, and cirrhosis

I Bazwinsky-Wutschke, A Zipprich… - International Journal of …, 2019 - mdpi.com
… -CoA carboxylase-1 (ACC) and fatty acid synthase (FAS) [25]. … CB 1 agonist increased the
de novo fatty acid (FA) synthesis … The activation of liver CB 1 receptors by endocannabinoids

Analysis of Direct Effects of the CB1 Receptor Antagonist Rimonabant on Fatty Acid Oxidation and Glycogenolysis in Liver and Muscle Cells in vitro

GA Müller, S Wied, AW Herling - Biochemistry (Moscow), 2019 - Springer
Endocannabinoids and cannabinoid receptors have been known for years as key players in
the control of food intake [1 4]. … isoform 4, as well as activated phosphorylation of adenosine …

The effect of CB1 antagonism on hepatic oxidative/nitrosative stress and inflammation in nonalcoholic fatty liver disease

B Jorgaĉević, D Vuĉević, J Samardžić… - Current medicinal …, 2021 - ingentaconnect.com
Cannabinoid receptor type 1 (CB1) expression is largely … arachidonic acid and other longchain
polyunsaturated fatty acids [2… of de novo synthesis in response to the activation of calcium-…

[PDF][PDF] Cannabinoid1 receptor antagonism improves glycemic control and increases energy expenditure through sirtuin‐1/mechanistic target of rapamycin complex 2 …

J Liu, G Godlewski, T Jourdan, Z Liu, R Cinar… - …, 2019 - Wiley Online Library
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and …
Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of …

High fat diet increases circulating endocannabinoids accompanied by increased synthesis enzymes in adipose tissue

EN Kuipers, V Kantae, BCE Maarse… - Frontiers in …, 2019 - frontiersin.org
activates adipose tissue depots to increase the synthesis … of these non-cannabinoid fatty
acid amides were raised in … Synthesis enzymes of 2-AG in liver and skeletal muscle were …

Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice

Q Yang, S Sun, W Liu, Q Liu, J Wang - Biochemical and biophysical …, 2020 - Elsevier
… role of liver endocannabinoid receptor CB1 in nutritional obese … -activation of CB1 receptors
impeded the HT regulated liver … enhance the liver fatty acid oxidation and reduce the liver fat

n-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1/adiponectin …

Y Chen, Z Fan, X Gao, F Zhou, X Guo… - The Journal of …, 2024 - Elsevier
… In the liver, CB1 activation by AEA and 2-AG increased de novo … novo fatty acid synthesis
and increase hepatic fatty acid oxidation, finally reducing hepatic TAG accumulation in the liver […

Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3-and ω6-long-chain-PUFA deficiency

I Hammels, E Binczek, I Schmidt-Soltau, B Jenke… - Journal of lipid …, 2019 - ASBMB
… Table 1 summarizes the GC/MS analysis of the fatty acid composition of the diets used for
the … TABLE 1GC/MS analysis of the fatty acid composition of the diets used for the …

Endocannabinoid system and its regulation by polyunsaturated fatty acids and full spectrum hemp oils

S Komarnytsky, T Rathinasabapathy, C Wagner… - International Journal of …, 2021 - mdpi.com
endocannabinoids do not activate classical CB1/2 receptors, … in a preclinical model of
hepatic injury, where MAGL … the modulation of distinct cannabinoid receptors promoted different …

Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma

J Yang, Y Tian, R Zheng, L Li, F Qiu - Oncology Letters, 2019 - spandidos-publications.com
… and activity of fatty acid amide hydrolase. Another important … agonist of the CB1 receptor,
and the activation of CB1 is beneficial … In the present study, a notable decrease of CB1 receptor