Targeted subcellular protein delivery using cleavable cyclic cell-penetrating peptides

AFL Schneider, ALD Wallabregue, L Franz… - Bioconjugate …, 2019 - ACS Publications
… we believe that the transport into the cells should ideally occur through a non-endocytic
pathway, as … 9 we conjugated cell-penetrating peptides 1 and 2 as before (Figure 3a). Again, the …

[HTML][HTML] Membrane internalization mechanisms and design strategies of arginine-rich cell-penetrating peptides

M Hao, L Zhang, P Chen - International Journal of Molecular Sciences, 2022 - mdpi.com
endocytosis and direct cell entry is critical in the cellular … highest cellular uptake of all the
oligoarginine-peptide conjugations. … -penetrating peptide (R 8 ) sequences in the nanoparticles

Application of advances in endocytosis and membrane trafficking to drug delivery

Y Ju, H Guo, M Edman, SF Hamm-Alvarez - Advanced drug delivery …, 2020 - Elsevier
… mechanisms responsible for endocytotic uptake of extracellular materials, which are also
the … Finally, options for intracellular trafficking and targeting of internalized DDS are briefly …

[HTML][HTML] Cell-penetrating peptides in protein mimicry and cancer therapeutics

M Zorko, S Jones, Ü Langel - Advanced drug delivery reviews, 2022 - Elsevier
… Finally, antibody/antigen CPP conjugates and their potential … able to use both direct and
endocytic routes of internalization. It … nanoparticles (AgNPs) decorated with either the cancer cell

Advances in the use of cell penetrating peptides for respiratory drug delivery

L Gomes dos Reis, D Traini - Expert Opinion on Drug Delivery, 2020 - Taylor & Francis
… to cross the cellular membrane using both endocytosis and … of insulin transport when
conjugated with oligoarginine (R9), … , and nanoparticles, to enhance the intracellular delivery of …

[HTML][HTML] Intracellular delivery of DNA and protein by a novel cell-permeable peptide derived from DOT1L

J Geng, X Guo, L Wang, RQ Nguyen, F Wang, C Liu… - Biomolecules, 2020 - mdpi.com
… ) and non-organic nanoparticles to liposomes are commonly … Therefore, we found that
endocytosis may not be the major … non-covalently conjugated plasmid and covalently conjugated

Cell penetration peptide-based nanomaterials in drug delivery and biomedical applications

Z Shariatinia - Biopolymer-Based Nanomaterials in Drug Delivery and …, 2021 - Elsevier
… The CPPs can transport numerous biologically active agents … receptors and their uptake by
cells through endocytosis. The … into cell penetrating peptide conjugated gold nanoparticles

Recent advances of anti-cancer therapies including the use of cell-penetrating peptides

A Klimpel, T Luetzenburg, I Neundorf - Current opinion in pharmacology, 2019 - Elsevier
… direct translocation or energy-dependent endocytosis [4]. One of … whole complex was
improved by conjugation of HA2, a subunit … of nanoparticles. Within this, Gan et al. screened for a …

[HTML][HTML] An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

BC Evans, RB Fletcher, KV Kilchrist, EA Dailing… - Nature …, 2019 - nature.com
penetrating peptides/protein transduction domains that are … gold based hybrid nanoparticles,
and the use of cell penetrating … utilizing a gold nanoparticle conjugated to cationic polymers …

[HTML][HTML] Prospect of cell penetrating peptides in stem cell tracking

X Zhang, T Lei, H Du - Stem Cell Research & Therapy, 2021 - Springer
… complex is mainly limited to endocytosis, but the TAT/small peptide complex is internalized
by … [90] designed a cell penetrating peptide (TAT)-conjugated, porous silicon nanoparticle (…