Internalization mechanisms of cell-penetrating peptides

I Ruseska, A Zimmer - Beilstein journal of nanotechnology, 2020 - beilstein-journals.org
Endocytosis as a mechanism for the transport of CPPs … the endocytic mechanisms used by
each CPP conjugate … The future fate of these structures is not entirely clear. Viruses are known …

Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives

AFL Schneider, M Kithil, MC Cardoso, M Lehmann… - Nature Chemistry, 2021 - nature.com
… uptake of protein–CPP conjugates in a non-endocytic mode, even at … conjugation of a single
TAT peptide can be used to transport … Our future work will be directed at making use of this …

An update on cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, Ü Langel - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
… with cells and whether particles were internalized in an endocytic or nonendocytic manner.
In any case, the transport of the virus particle to the cellconjugates (mitFects) for intracellular

Cell-penetrating peptide-conjugated lipid/polymer hybrid nanovesicles for endoplasmic reticulum-targeting intracellular delivery

JY Kang, S Kim, J Kim, NG Kang, CS Yang… - Journal of Materials …, 2021 - pubs.rsc.org
… to the plasma membrane through vesicle trafficking, enabling post-… -PEO induced ATP-dependent
endocytosis. These observations … Subsequent fate of the LPNV Pnt is unknown, but we …

Cell-Penetrating and Targeted Peptides Delivery Systems as Potential Pharmaceutical Carriers for Enhanced Delivery across the Blood–Brain Barrier (BBB)

SM Ghorai, A Deep, D Magoo, C Gupta, N Gupta - Pharmaceutics, 2023 - mdpi.com
… shuttles, and brain-permeable peptide–drug conjugates (… endocytosis (CME), the interaction
of peptides with specific … vehicles conjugated to peptides were designed for transport to the …

The utilization of cell-penetrating peptides in the intracellular delivery of viral nanoparticles

J Váňová, A Hejtmánková, MH Kalbáčová… - Materials, 2019 - mdpi.com
… as nanocontainers for the efficient transport of nucleic acids (DNA… target cells and utilize
various endocytic pathways for the … delivery of a cargo [27,75], Ad with covalently conjugated Tat …

Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines

SG Patel, EJ Sayers, L He, R Narayan, TL Williams… - Scientific reports, 2019 - nature.com
… large active proteins to enter cells via endocytosis 4,5,6 . … by flow cytometry analysis of the
same conjugates (Fig. 2b). … For treatments of lysosomal storage diseases, rapid trafficking

Cell-penetrating peptides delivering siRNAs: an overview

L Falato, M Gestin, Ü Langel - Design and Delivery of SiRNA Therapeutics, 2021 - Springer
… most promising use for CPPs in future clinical applications. … used to conjugate the cargo
and the carrier: peptides linked … The complexes were able to enter the cells via endocytic

Nanoparticles modified with cell-penetrating peptides: Conjugation mechanisms, physicochemical properties, and application in cancer diagnosis and therapy

I Gessner, I Neundorf - International journal of molecular sciences, 2020 - mdpi.com
… versatile vehicles for the intracellular transport of various cargos, … On the other hand,
endocytosis is mainly observed when larger … fate of conjugates in comparison to their individual …

Cell-penetrating peptides

M Zorko, Ü Langel - Cell penetrating peptides: methods and protocols, 2022 - Springer
… into the cells, where direct and endocytic internalization of … , uptake, intracellular trafficking
and siRNA uptake [32]. In … [104], dual peptide conjugation strategy of a mitochondrial targeting …