… of glomerularor tubular cells, glomerulosclerosis, and tubulointerstitial fibrosis 2 . …
induction in maintaining lysosomal function and protecting podocytes from injury in diabetes …

… These mice were protected against diabetes-induced podocyte loss and glomerulosclerosis
but also provide … Similarly, endothelial-selective autophagy inhibition also promotes …

… , we were able to prevent podocyte apoptosis in culture. The … Importantly, alteration of
autophagy by endothelial cell … to podocyte depletion, albuminuria and glomerulosclerosis in DKD. …

… progressive podocyte loss accelerates glomerulosclerosis … to enhance autophagy and
protect podocytes from high … IV exerts synergistic effects on the regulation of autophagy[161…

… Analogously, in vivo, podocyte loss, glomerulosclerosis, and proteinuria were increased
in … , helping to prevent progression to FSGS in these settings. In this context, inhibition of …

… (GMCs) and glomerular endothelial cells (GECs), seems to … suggests that endothelial
autophagy might protect glomeruli … 44 ; podocyte loss and progressive glomerulosclerosis were …

… A high level of autophagy in podocytes is necessary to keep … the disturbed autophagy in
glomerular endothelial cells and … , which lead to glomerulosclerosis and tubulointerstitial fibrosis (…

… autophagy to prevent renal fibrosis and related kidney diseases. … and glomerulosclerosis
in podocyte-specific autophagy-… endothelial cells and surrounding podocytes autophagy in …

… and the efficient removal of damaged proteins and organelles from the cells to prevent
apoptosis. Activation of the JAK/STAT pathway aggravates the progression of DKD and damage …

… podocytes, glomerular basement membrane and endothelial … synergistically activate ULK1
and thereby induce autophagy … L1)-associated focal segmental glomerulosclerosis (FSGS), …