… cell types, including pulmonary arterial endothelial cells (… specific death ligands binding to
the death receptors (18). … and suppressing endothelin synthesis through negative regulation of …

… hypoxic … hypoxia signaling pathways have been established. Thus, it is the time to summarize
and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms …

… of Fas/Fas-ligand and estrogen-regulated protein kinase signaling … by hypoxia/reoxygenation
injury in H9c2 cells by regulating the AKT/mTOR pathway. In addition, the down-regulation …

… HFD-mediated hypercholesterolemic models (rats and rabbits… and subsequent down-regulation
regulation of NF-кB … pulmonary arterial pressure (mPAP) in hypoxic animals and …

… the role of hypoxia-mediated epigenetic regulation in cancer, … -α, and CC motif chemokine
ligand 2 (CCL2) of mouse and … mediated down-regulation of specific T regulatory lymphocytes …

… as vasoconstrictor peptides produced by vascular endothelial cells. ET-1 is … several factors,
including cytokines, hypoxia, and ET-1 itself [54,55,56]. … Classification of endothelin receptors. …

… by HIF-1α–driven CXC motif chemokine ligand 12 (CXCL12) … in pulmonary vascular endothelial
and smooth muscle cells … mice and rats) and in vascular cells isolated from PH patients …

… , anti-fibrosis and vascular endothelial protection, there is still … growth factor (PDGF) and
hypoxia inducible factor-1α (HIF-1α… γ, the down-regulation of CAM, and the regulation of NF-κ B …

… stimulatory receptors such as ANG II, endothelin-1, hypoxia, … shown to activate ERs in
vascular endothelial cells (ECs), in … and endothelin receptor inhibitors improve vascular diastole …

… regulation of inflammation, attenuation of astrogliosis and microglial activation, prevention
of excitotoxicity and as a consequence the reduction of neuronal cell … p38 that mediates the …