… its ligand EGF binding are the main causes of squamous cell … synthesis of VEGF induced by
hypoxia and endothelin at the … activation in rat peritoneal macrophages and dendritic cells as …

… hypoxia directly damage the local vascular system, leading to necrosis and dissociation
of vascular endothelial cells, … The mechanism may be related to down-regulation of TLR4/NF-κB …

… CK-19), portal vascular endothelial cells (vWF), macrophages (… fibrosis in BDL rats but did
not evaluate the cellular targets. We … Mdk induces neovascularization under hypoxic conditions …

… ; (iii) endothelin receptor antagonists, … down-regulation by acting as a TNF-alpha ligand
trap PAECs and PASMCs 51 MCT rat 153 ; endotoxaemic pigs 154 ; SU-416 hypoxia rats …

… In cancer cell studies, these multiple ligand receptor … lysophosphatidic acid (LPA), thrombin,
and endothelin-1 mediate … Hypoxia requires EGFR-mediated ERK activation in human …

… endothelin-receptor blockade and down regulation of … 3 deficiency lead to attenuation of
chronic hypoxia-induced PH [37]. … regulated genes were chemokine (CC motif) ligand 11 (Ccl11…

… vascular endothelial growth factor … homeostasis through a variety of mechanisms such as
anti-inflammation, … -γ or LPS, the latter being a ligand for toll-like receptor 4. HIF-2α is activated …

… main topic of the current review—the vascular endothelium … of hypoxia/reoxygenation (H/R)
injury, severe inflammation, or … permeability induced by ATP in a rat model [47]. It is worth …

… This data implies that IL-18 down regulation of VEGF is not … manner, hypoxic human
pulmonary artery endothelial cells (… The vascular endothelium forms a barrier that regulates the …

… are perfused with hypoxic solutions, cell or tissue damage is … leading to receptor desensitization
and/or down-regulation, … I/R injury to the liver, impairing vascular endothelial function …