Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis

H Zhang, Z Bai, L Zhu, Y Liang, X Fan, J Li… - European Journal of …, 2020 - Elsevier
… that NaHS attenuated the down-regulation of CSE protein … NaHS could protect arterial
endothelial cells by suppressing … H 2 S can also protect hypoxia-induced injury in HUVECs [58]. In …

[HTML][HTML] The epithelial-to-mesenchymal transition as a possible therapeutic target in fibrotic disorders

J Di Gregorio, I Robuffo, S Spalletta… - Frontiers in cell and …, 2020 - frontiersin.org
… the key mediator of cellular response to hypoxia, the hypoxia-… Down-regulation of the mir-29
family members is associated … vascular endothelial growth factor (VEGF) 1, 2, 3, receptors. …

The role of toll-like receptors in myocardial toxicity induced by doxorubicin

C Xinyong, Z Zhiyi, H Lang, Y Peng, W Xiaocheng… - Immunology letters, 2020 - Elsevier
… on the cell surface to form a stable receptor-ligand complex … tolerance of myocardial cells to
ischemia and hypoxia. Recent … and prevents the down-regulation of transcription factor gat-4.…

[HTML][HTML] The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia

I Psilopatis, K Vrettou, FN Fleckenstein, S Theocharis - Cells, 2023 - mdpi.com
… signaling pathway [55], while hypoxia has been suggested to have a negative … and
vascular endothelium, while PPARγ expression was determined to exhibit significant down-regulation

[HTML][HTML] Biological activities of paeonol in cardiovascular diseases: a review

S Vellasamy, D Murugan, R Abas, A Alias, WY Seng… - Molecules, 2021 - mdpi.com
… using human umbilical vascular endothelial cells (HUVECs) … , the binding of death ligands
such as Fas ligand (FasL) or … glycogen synthase followed by down-regulation of apoptotic and …

[HTML][HTML] Immune and apoptosis mechanisms regulating placental development and vascularization in preeclampsia

N Raguema, S Moustadraf, M Bertagnolli - Frontiers in physiology, 2020 - frontiersin.org
… not occur, resulting in tissue hypoxia. In addition, the failure of … pro-angiogenic factors vascular
endothelial growth factor (VEGF… on the surface binds to its FAS ligand (FASL), activating a …

[HTML][HTML] Substances of interest that support glaucoma therapy

SC Saccà, P Corazza, S Gandolfi, D Ferrari, S Sukkar… - Nutrients, 2019 - mdpi.com
… action through the down-regulation of cytokines such as TNF-… by GBE protects the vascular
endothelium [139] and rat spinal … mediator in hypoxic ischemic brain injury in the newborn rat. …

[HTML][HTML] Genetic delivery and gene therapy in pulmonary hypertension

N Rai, M Shihan, W Seeger, RT Schermuly… - International Journal of …, 2021 - mdpi.com
… that lead to restoration or down-regulation of gene expression, … -induced pulmonary vascular
endothelial injury/dysfunction, … protected rat lungs exposed to chronic hypoxia against PH …

[HTML][HTML] Protective effects of estrogen on cardiovascular disease mediated by oxidative stress

D Xiang, Y Liu, S Zhou, E Zhou, Y Wang - … medicine and cellular …, 2021 - hindawi.com
… an important role in vascular endothelial cells, which are … In a hypoxia and reoxygenation
model of rat cardiomyocytes in … Cosic et al., “Selective downregulation of mitochondrial electron …

[HTML][HTML] Nuclear receptors in myocardial and cerebral ischemia—mechanisms of action and therapeutic strategies

J Rzemieniec, L Castiglioni, P Gelosa… - International Journal of …, 2021 - mdpi.com
… strategies to protect myocardial and brain cells against hypoxia/… significantly influence cell’s
response to various ligands. … fibrosis in rats via up-regulation of PPAR-γ, down-regulation of …