Noise-induced cochlear damage involves PPAR down-regulation through the interplay between oxidative stress and inflammation

F Paciello, A Pisani, R Rolesi, V Escarrat, J Galli… - Antioxidants, 2021 - mdpi.com
… PPARs comprise a family of three ligand-regulated … -oxidative stress in vascular endothelial
cells attenuates PPARγ … and PPAR down-regulation in mediating cochlear damage. In fact, …

25-hydroxyvitamin D3 inhibits oxidative stress and ferroptosis in retinal microvascular endothelial cells induced by high glucose through down-regulation of miR-93

D Zhan, J Zhao, Q Shi, J Lou, W Wang - BMC ophthalmology, 2023 - Springer
… patients as well as vision protection by reducing vascular leakage [3… NV by down-regulation
of HIF-mediated transcription in … reported the synthetic ligands of the vit D receptor can target …

Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis

P Ahmad, SS Alvi, D Iqbal, MS Khan - Life sciences, 2020 - Elsevier
… of LDL to the endothelial surface, expose endothelial receptors and enhance binding of …
protection against FHF via reducing serum ALT and AST activities and down-regulation of …

CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression

Z Yang, P Li, Q Shang, Y Wang, J He, S Ge, R Jia… - Science …, 2020 - science.org
… Natural killer (NK) cells protect against obesity and metabolic … Ligand-receptor complexes
recruit and phosphorylate the … factor regulating hepatic TG homeostasis and the mechanism of …

COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease

D Tomasoni, L Italia, M Adamo… - European journal of …, 2020 - Wiley Online Library
… Virus-mediated down-regulation of ACE2 may increase … ligand/receptor complex and
subsequent intracellular degradation. … on the surface of coronary endothelial cells, cardiomyocytes …

Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis

H Zhang, Y Wang, M Qu, W Li, D Wu… - Clinical and …, 2023 - Wiley Online Library
… the blood to the infection site, responding to CXC ligand 2 (… , 128 maintaining endothelial
integrity and protecting cells fromdown-regulation of TM, and these effects are partly mediated

Cannabinoid receptor 2 deletion deteriorates myocardial infarction through the down-regulation of AMPK-mTOR-p70S6K signaling-mediated autophagy

Y Hu, Y Tao, J Hu - Bioscience Reports, 2019 - portlandpress.com
… a hypothesis that activating CB2R protects against MI through the induction of autophagy.
We aim to explore new mechanisms of MI and develop novel therapeutic strategy against MI. …

[HTML][HTML] mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5

W Wang, YE Zhang, L Wang, J Li, Y Li, X Yang… - Biomedicine & …, 2019 - Elsevier
… of human umbilical vein endothelial cell, suggesting that miR-… of IL-1, IL-6 and TNF-α mediated
by ox-LDL in the cultural … Wnt ligand gathers a Frizzled receptor and a LRP co-receptor [31…

Size matters: the functional role of the CEACAM1 isoform signature and its impact for NK cell-mediated killing in melanoma

I Helfrich, BB Singer - Cancers, 2019 - mdpi.com
… by down-regulation of ligands of the NKG2D receptor. On … , like activated fibroblasts and
endothelial cells. The multicellular … , which led to protection from T-cell-mediated liver injury [96]. …

Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation

UV Wesley, IC Sutton, K Cunningham… - Journal of Cerebral …, 2021 - journals.sagepub.com
… showed down regulation of pro-apoptotic and inflammatory genes including Fas-ligand, and
… clotting tendencies as well as endothelial dysfunction. We next investigated the molecular …