The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke

W Hou, Y Hao, L Sun, Y Zhao, X Zheng, L Song - Molecular Brain, 2022 - Springer
regulating GPCRs-mediated autophagy. This review aims to systematically discuss the
underlying mechanism … ischemia, and describe the GPCRs-mediated autophagy, hoping to probe …

[HTML][HTML] mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5

W Wang, YE Zhang, L Wang, J Li, Y Li, X Yang… - Biomedicine & …, 2019 - Elsevier
… of human umbilical vein endothelial cell, suggesting that miR-… of IL-1, IL-6 and TNF-α mediated
by ox-LDL in the cultural … Wnt ligand gathers a Frizzled receptor and a LRP co-receptor [31…

Cannabinoid receptor 2 deletion deteriorates myocardial infarction through the down-regulation of AMPK-mTOR-p70S6K signaling-mediated autophagy

Y Hu, Y Tao, J Hu - Bioscience Reports, 2019 - portlandpress.com
… a hypothesis that activating CB2R protects against MI through the induction of autophagy.
We aim to explore new mechanisms of MI and develop novel therapeutic strategy against MI. …

ALK7 acts as a positive regulator of macrophage activation through down-regulation of PPARγ expression

WL Cheng, Q Zhang, JL Cao, XL Chen, W Li… - … of Atherosclerosis and …, 2021 - jstage.jst.go.jp
… The endothelial dysfunction initiates the atherosclerosis … , from ligands, receptors, and
binding proteins to ligand traps, … against macrophage activation were partially mediated by up…

Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle …

Y Guo, C Xu, AWC Man, B Bai, C Luo… - Cardiovascular …, 2019 - academic.oup.com
… Age-induced down-regulation of sGC and up-regulation of … signalling mechanisms underlying
endothelial SIRT1-mediated … of the Notch ligand Jagged1 in endothelial cells and Notch …

COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease

D Tomasoni, L Italia, M Adamo… - European journal of …, 2020 - Wiley Online Library
… Virus-mediated down-regulation of ACE2 may increase … ligand/receptor complex and
subsequent intracellular degradation. … on the surface of coronary endothelial cells, cardiomyocytes …

Size matters: the functional role of the CEACAM1 isoform signature and its impact for NK cell-mediated killing in melanoma

I Helfrich, BB Singer - Cancers, 2019 - mdpi.com
… by down-regulation of ligands of the NKG2D receptor. On … , like activated fibroblasts and
endothelial cells. The multicellular … , which led to protection from T-cell-mediated liver injury [96]. …

… anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins …

T Knox, E Sahakian, D Banik, M Hadley, E Palmer… - Scientific reports, 2019 - nature.com
… program death ligand-1 (PD-L1) and programmed death ligand-2 (PD-… This regulatory
mechanism is mediated by STAT3, which … and host defense mechanism against malignancies 53 . …

[HTML][HTML] MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization

X Zhu, H Liu, Z Zhang, R Wei, X Zhou… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
… Moreover, down-regulation of miR-103 could sensitively … targeting chemokine (CC motif)
ligand 13 (CCL13) and ADAM … that the underlying mechanisms of miRNA regulated RSA are …

[HTML][HTML] Vitamin D deficiency in association with endothelial dysfunction: Implications for patients withCOVID-19

J Zhang, PA McCullough, KM Tecson - Reviews in cardiovascular …, 2020 - imrpress.com
… Conversely, vitamin D supplementation protects against an … D, (2) vitamin D receptor and
vitamin D receptor ligand, (3) … that it may be mediated by NF- κ B down-regulation. Kundu et al. (…