Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation

UV Wesley, IC Sutton, K Cunningham… - Journal of Cerebral …, 2021 - journals.sagepub.com
… showed down regulation of pro-apoptotic and inflammatory genes including Fas-ligand, and
… clotting tendencies as well as endothelial dysfunction. We next investigated the molecular …

Mechanisms of action of metformin and its regulatory effect on microRNAs related to angiogenesis

G Wang, F Lin, Q Wan, J Wu, M Luo - Pharmacological Research, 2021 - Elsevier
mechanism underlying the metformin-mediated regulation of … of vascular endothelial growth
factor receptors (VEGFR) [16], … angiogenesis via regulating the PTPRD- CXC motif ligand 8 (…

Inactivation of endothelial adenosine A2A receptors protects mice from cerebral ischaemia‐induced brain injury

Y Zhou, X Zeng, G Li, Q Yang, J Xu… - British Journal of …, 2019 - Wiley Online Library
… post-stroke outcomes via down-regulation of inflammation. … other possible mechanisms in
A 2A receptor-mediated, post-… A 2A receptors in brain endothelial cells mediate inflammation …

[HTML][HTML] SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis

DL Ruter, Z Liu, KM Ngo, A Marvin, DB Buglak… - Angiogenesis, 2021 - Springer
… -associated genes and down regulation of junction-associated … arterial laminar flow with
protection from atherosclerosis, and … the ligand Dll4 and requires Notch-mediated transcription (…

Mechanisms of podocyte injury and implications for diabetic nephropathy

F Barutta, S Bellini, G Gruden - Clinical Science, 2022 - portlandpress.com
… Nephrin down-regulation is observed in early human DN and correlates with both albuminuria
… , glomerular endothelial cells (GECs) and mesangial cells release slit guidance ligand 2 (…

HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation‐induced transendothelial permeability by elevating PPARγ activity in vitro

Q Zhao, Z Yu, F Zhang, L Huang, C Xing… - Journal of …, 2019 - Wiley Online Library
… junction protein Claudin-5 down-regulation. And these effects … activity is regulated by various
endogenous ligands and post-… protects against OGD/R-induced cerebral endothelial barrier …

[HTML][HTML] The role of KLF2 in the regulation of atherosclerosis development and potential use of KLF2-targeted therapy

SA Dabravolski, VN Sukhorukov, VA Kalmykov… - Biomedicines, 2022 - mdpi.com
… role in regulating atheroprotective effects in endothelial cells. We … in activating various defense
mechanisms against OS and … also participates in DF-mediated KLF2 down-regulation [37]. …

[HTML][HTML] Tumor angiogenesis: causes, consequences, challenges and opportunities

R Lugano, M Ramachandran, A Dimberg - Cellular and Molecular Life …, 2020 - Springer
… of cellular and molecular mechanisms involved in tumor … neo-vascularization from endothelial
progenitor cells. The … recurrence after irradiation is mediated by vasculogenesis and not …

Vitamin E: regulatory role on signal transduction

JM Zingg - IUBMB life, 2019 - Wiley Online Library
… to cultured vascular endothelial cells by down-regulating CD36 … -regulated by its ligand LDL,
the CD36 scavenger receptor is … vitamin E and atorvastatin by down-regulation of CD36, but …

[HTML][HTML] Impairment of NKG2D-mediated tumor immunity by TGF-β

M Lazarova, A Steinle - Frontiers in immunology, 2019 - frontiersin.org
… the surface of regulatory T cells (Tregs), endothelial cells, platelets… ligand, or without affecting
NK cell viability, indicating that … TGF-β-mediated down-regulation of NKG2D and associated …