Mechanisms of podocyte injury and implications for diabetic nephropathy

F Barutta, S Bellini, G Gruden - Clinical Science, 2022 - portlandpress.com
… Nephrin down-regulation is observed in early human DN and correlates with both albuminuria
… , glomerular endothelial cells (GECs) and mesangial cells release slit guidance ligand 2 (…

Silibinin protects rat pancreatic β‐cell through up‐regulation of estrogen receptors' signaling against amylin‐ or Aβ1–42‐induced reactive oxygen species/reactive …

J Yang, Y Sun, F Xu, W Liu, T Hayashi… - Phytotherapy …, 2019 - Wiley Online Library
regulatory mechanisms of ERs function. We suspect that silibinin regulates phosphorylation
of ERs mediated … Our results indicate that down-regulation of GLP-1R and PKA leads to INS-…

Aberrant activation of Notch1 signaling in glomerular endothelium induces albuminuria

L Li, Q Liu, T Shang, W Song, D Xu, TD Allen… - Circulation …, 2021 - Am Heart Assoc
… or treatment with Notch ligand DLL4 (delta-like ligand 4) … novel regulatory mechanisms
whereby endothelial Notch1 … /loxP-mediated DNA recombination and tetracycline-regulated

[HTML][HTML] Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations

X Li, Y Yang, Z Wang, S Jiang, Y Meng… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
endothelial growth factor receptor 2 (VEGFR2) and its ligand … miR-27b down regulation
targets Naa15 regulates the activity … the regulation of unstable plaques via mediating functions of …

Lipid raft association stabilizes VEGF receptor 2 in endothelial cells

IO Zabroski, MA Nugent - International Journal of Molecular Sciences, 2021 - mdpi.com
… important role in ligand induced activation of associated receptors and … the down regulation
of VEGFR2, which may be part of the … reducing VEGF mediated signaling in endothelial cells. …

IFNγ receptor down-regulation facilitates Legionella survival in alveolar macrophages

C Yang, DS McDermot, S Pasricha… - Journal of leukocyte …, 2020 - academic.oup.com
… Type I IFN-mediated down-regulation of IFNGR1 during Listeria … found that the mechanism
for IFNGR down-regulation was … Other TLR ligands may also produce similar effects on …

[HTML][HTML] Overview of bile acid signaling in the cardiovascular system

R Zhang, WQ Ma, MJ Fu, J Li, CH Hu… - World Journal of …, 2021 - ncbi.nlm.nih.gov
… putative mechanism of this effect includes activating the ligand … LCA down-regulation of
glycogen synthase kinase-3 and up-… endothelial cells by down-regulating endothelin-1 (IL-1), up-…

RETRACTED ARTICLE: Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway

HM Huang, XH He, XY Huang, GY Wang… - Cell Communication and …, 2022 - Springer
… altered functions and mechanisms after down regulating KOR. … that down-regulated KOR
mediated actin cytoskeleton … whether KOR nature ligands take part in the regulation of ESCC, …

Estrogen-related mechanisms in sex differences of hypertension and target organ damage

AR Sabbatini, G Kararigas - Biology of sex differences, 2020 - Springer
… In addition, endothelin (ET) was shown to mediate increases in BP in old female SHR […
regulatory effects of E2 include the down-regulation of peroxisome proliferator-activated receptor-…

Lignans from Schisandra chinensis ameliorate alcohol and CCl4-induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR

JB Xu, GC Gao, MJ Yuan, X Huang, HY Zhou… - Journal of …, 2020 - Elsevier
… The in silico analysis results indicated that endothelin receptor … a co-crystallized ligand (PDB
ID: 5X93 ) was downloaded from … 11A and B indicated the obvious down-regulation of ETBR …