Disease modification trials in Parkinsons disease: a review

RN Hashmi, U Kiram - Pakistan Journal of Neurological …, 2020 - ecommons.aku.edu
levodopa on motor complications of Parkinson's disease) was carried out in order to compare
Pramipexol with levodopa18. Patients on … the results showed modulation of various factors …

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
… However, little is known about the molecular and cellular mechanisms of aging and PD-induced
NSC down-modulation. Based on our own studies and the background literature, the …

What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson's Disease?

J Xue, K Tao, W Wang, X Wang - International Journal of Molecular …, 2024 - mdpi.com
… expression level can modulate inflammatory reactions [… Endurance training exerted a
suppressive effect on the expression of α-synuclein and counteracted neuroinflammation induced

Impact of nutrition, microbiota transplant and weight loss surgery on dopaminergic alterations in Parkinson's Disease and Obesity

S Hamamah, A Hajnal, M Covasa - International journal of molecular …, 2022 - mdpi.com
… In this review, we first examine the role of prominent food groups on dopamine bioavailability,
how they modulate the composition and function of the gut microbiota and the subsequent …

Dietary Restriction against Parkinson's Disease: What We Know So Far

Z Wang, Y Cui, L Wen, H Yu, J Feng, W Yuan, X He - Nutrients, 2022 - mdpi.com
… that DR modulates brain … induced by daytime levodopa or carbidopa treatment were
significantly alleviated by eliminating dietary proteins from breakfast and lunch, and the patient’s …

[HTML][HTML] Program of seven 45-min dry immersion sessions improves choice reaction time in Parkinson's disease

AY Meigal, OG Tretjakova… - Frontiers in …, 2021 - frontiersin.org
The study hypothesis held that in subjects with Parkinson’s disease (PD), the reaction time (RT)
tests of the higher cognition demand would have more readily improved under the …

Ferroptosis as a new mechanism in Parkinson's disease therapy using traditional Chinese medicine

L Wu, M Liu, J Liang, N Li, D Yang, J Cai… - Frontiers in …, 2021 - frontiersin.org
… on PD, such as levodopa, can treat patients with early PD, but … and pace, increase their
endurance, enhance their control of their … Progesterone receptor modulates neuroprotective and …

Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR

S Barati, C Fabrizio, C Strafella, R Cascella, V Caputo… - Genes, 2022 - mdpi.com
… On this subject, the introduction of nutrigenomics shed light on the main molecular players
involved in the modulation of health and disease status. In particular, the review presents data …

[HTML][HTML] Pharmacological targeting of microglial activation: new therapeutic approach

CY Liu, X Wang, C Liu, HL Zhang - Frontiers in cellular neuroscience, 2019 - frontiersin.org
… may contribute to the induction and modulation of inflammation in PD… Interestingly, endurance
exercise could exert … Interestingly, ghrelin, an endogenous ligand for growth hormone

[HTML][HTML] Understanding how physical exercise improves Alzheimer's disease: cholinergic and monoaminergic systems

B Zong, F Yu, X Zhang, W Zhao, P Sun… - Frontiers in Aging …, 2022 - frontiersin.org
… Most neurotransmitters and neurotransmitter-related drugs modulate the pathology of AD
and improve cognitive function through G protein-coupled receptors (GPCRs). Exercise