Patient-oriented research is an emerging approach that engages patients, clinicians, and researchers to ensure focus on patient-identified priorities. 1 From a clinical perspective, involving patients in medical decisions is required by law and professional code (ie, informed consent). Informed consent requires evidence that is pertinent to the decision at hand, but also information that is deemed relevant by the decision maker (the patient). Despite the importance of research in providing evidence to inform such clinical decisions, engaging patients in clinical research is not frequently done, is often suboptimal, and is not required by regulations and good practice. The failure to engage patients in clinical research has led to large swathes of research that neither addresses