… materials for biomedical and tissue engineering applications. … with a defined topography at
micro- or nanoscale—see Figure … nanoscale patterned substrates are more prone to influence …

… cells’ response to topographical cues (micro/nanoscale patterns) is one of the fundamental
topics in the field of regenerative medicine. The fate of cells … by the substrate topography. For …

… Precise engineering of 2D nanopatterns and 3D … to study the cellular responses to specific
topographic features. In … support the growth of cell adhesion on soft substrates. These results …

… normally found on 2D substrates: cells adhered on the structure … Here, from our findings on
the topography-mediated … the cellular internalization bypassing the vector engineering step …

… for this cellular sensitivity to topography at the nanoscale. This … a critical contribution to
tissue-engineering studies for future … substrate topography, are detected and processed by a cell …

… engineered substrates with analogous nanoscale features … substrate topography is partly
attributed to adhesion-related mechanisms [74]. The cells can sense the different topographic …

… such as substrate rigidity, surface topography, and cellular … application of microfluidic
devices for engineering hPSCs. … Within native tissues, cells interact with different nanoscale …

… substrate engineering on the nanoscale are thoroughly scrutinized to highlight their significance
in micro… 3d, where both images provide detailed information on the material topography. …

The hypothesis of the present research is that by altering the substrate topography and/or
stiffness to make it biomimetic, we can modulate cells behavior. Substrates with similar surface …

… engineering topographies include microscale or nanoscale … surface topography regulating
the activities of corneal cells, … expanding studies incorporating substrate topography into the …