Inducible nitric oxide synthase: Regulation, structure, and inhibition
MA Cinelli, HT Do, GP Miley… - Medicinal research …, 2020 - Wiley Online Library
… or stimulated, typically by proinflammatory cytokines and/or … Low expression of kalirin is
correlated with increased iNOS … that imidazoles (Figure 10) can coordinate the heme iron of NOS …
correlated with increased iNOS … that imidazoles (Figure 10) can coordinate the heme iron of NOS …
[HTML][HTML] Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level
V Somasundaram, AC Gilmore, D Basudhar… - Redox Biology, 2020 - Elsevier
… We found increased cellular lactate in both WT and Nos2 −/− … While the induction of a
proinflammatory cytokine storm in … to determine their x,y coordinates with respect to the opening in …
proinflammatory cytokine storm in … to determine their x,y coordinates with respect to the opening in …
Regulation of cytochrome P450 enzyme activity and expression by nitric oxide in the context of inflammatory disease
… has been associated with inflammatory cytokines and their … the actions of three forms of
nitric oxide synthase (NOS) (Bredt … can be either inhibited or enhanced by substrates, and this …
nitric oxide synthase (NOS) (Bredt … can be either inhibited or enhanced by substrates, and this …
[HTML][HTML] Oxidative stress orchestrates MAPK and nitric-oxide synthase signal
T Takata, S Araki, Y Tsuchiya, Y Watanabe - International journal of …, 2020 - mdpi.com
… stress by disturbing the redox balance in vivo [22]. In aerobic … and nitrogen stresses, and
there is coordination among S-… levels of and the activities of RSK1/RSK2 are increased in …
there is coordination among S-… levels of and the activities of RSK1/RSK2 are increased in …
[HTML][HTML] Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation
JD Bailey, M Diotallevi, T Nicol, E McNeill, A Shaw… - Cell reports, 2019 - cell.com
… ) elicits the expression of inducible nitric oxide synthase (iNOS)… both an enhanced response
to, and synthesis of, specific … our data revealed significant co-ordinated decreases in 5 out of …
to, and synthesis of, specific … our data revealed significant co-ordinated decreases in 5 out of …
[HTML][HTML] Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury
… -Arg) by the catalysis of nitric oxide synthases (NOS). To make … for cell internalization further
in vivo applications. Additionally, … pro-inflammatory cytokines were significantly increased in …
in vivo applications. Additionally, … pro-inflammatory cytokines were significantly increased in …
The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity
… A series of heme proteins, nitric oxide synthases (NOS), … oxide synthase (NOS) in vivo. The
NOS enzymes are known … to increased vulnerability to O 2 and ultimately increased killing of …
NOS enzymes are known … to increased vulnerability to O 2 and ultimately increased killing of …
Nitric oxide: physiological functions, delivery, and biomedical applications
… by eNOS stimulate pro-inflammatory cytokines such as … NO production can also be enhanced
by the coordinated action … inhibition of cancer cells both in vitro and in vivo.[187] This light-…
by the coordinated action … inhibition of cancer cells both in vitro and in vivo.[187] This light-…
[HTML][HTML] Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
EM Palmieri, M Gonzalez-Cotto, WA Baseler… - Nature …, 2020 - nature.com
… the product of inducible nitric oxide synthase (iNOS or Nos2), … takes place through the
coordinated suppression of IDH1, SDH, … , a functional TCA and better stabilization of Keap1 (Kelch-…
coordinated suppression of IDH1, SDH, … , a functional TCA and better stabilization of Keap1 (Kelch-…
Molecular mechanisms of nitric oxide in cancer progression, signal transduction, and metabolism
V Somasundaram, D Basudhar… - Antioxidants & Redox …, 2019 - liebertpub.com
… by inducible nitric oxide synthase/nitric oxide synthase 2 (… cells increased the aggressiveness
of these cells in vivo into … coordinate to favor increase in NOS2 activity and increased …
of these cells in vivo into … coordinate to favor increase in NOS2 activity and increased …