[PDF][PDF] Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

LV Dissanayake, A Zietara, V Levchenko, DR Spires… - Iscience, 2022 - cell.com
… when UA is catalyzed by Xanthine Oxidase (XO), producing … /Ā rats, we saw increased
expression of Tgfb1, which might … Accordingly, we saw that hypouricemic rats failed to manage …

Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes

M Fujishiro, H Ishihara, K Ogawa, T Murase… - Biomedicines, 2021 - mdpi.com
… between plasma xanthine oxidoreductase (XOR) and diabetic vascular complications,
especially distal symmetric polyneuropathy (DSP), we investigated plasma XOR activities using a …

NADPH oxidases in diastolic dysfunction and heart failure with preserved ejection fraction

JP Teuber, K Essandoh, SL Hummel, NR Madamanchi… - Antioxidants, 2022 - mdpi.com
… distinct redox signaling mechanisms in cardiac myocytes pertinent to the onset and
progression of cardiac hypertrophy and heart failure. Heart failure with preserved ejection fraction (…

Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic …

S Sunagawa, T Shirakura, N Hokama… - Journal of diabetes …, 2019 - Wiley Online Library
… Furthermore, multiple regression analyses showed that the value of plasma XO activity is
associated with cardiovascular events and its future risk in patients with chronic heart failure12. …

Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway

MF An, MY Wang, C Shen, ZR Sun, YL Zhao… - Journal of natural …, 2021 - Springer
… Accumulating evidence suggests that high expression of XOD … ], pro-inflammatory responses
in heart failure [14], and insulin … Moreover, increased xanthine oxidase activity and uric acid …

Protective effect of febuxostat in sepsis-induced liver and kidney injuries after cecal ligation and puncture with the impact of xanthine oxidase, interleukin 1β, and c …

YF Ibrahim, RR Fadl, SAE Ibrahim… - Human & …, 2020 - journals.sagepub.com
… dismutase activity and total antioxidant capacity. In addition, CLP caused increased expression
… organ failure in sepsis. In our study, we found that there was an increase in IL-1β protein …

Novel reversible inhibitors of xanthine oxidase targeting the active site of the enzyme

R Rullo, C Cerchia, R Nasso, V Romanelli… - Antioxidants, 2023 - mdpi.com
Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are different cytosolic forms of
a single gene transcript named xanthine oxidoreductase (XOR) [1]. In humans, both forms of …

The effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, on arterial stiffness in hyperuricemic patients with liver dysfunction: a sub-analysis of the …

Y Fujishima, H Nishizawa, Y Kawachi, T Nakamura… - Biomedicines, 2023 - mdpi.com
xanthine oxidoreductase (XOR) inhibitors on the development of cardiovascular diseases
remain controversial. Based on recent findings that plasma XOR activity increased … XOR activity

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
… , heart failure and cardiac arrhythmias. Interactions between different oxidases or oxidase
… ; also known as NOS3), mitochondria and xanthine oxidase (XO) 1 . NOX is distinct from …

Role of oxidative stress in heart failure: insights from gene transfer studies

B De Geest, M Mishra - Biomedicines, 2021 - mdpi.com
… Other sources of ROS are NADPH oxidases, xanthine oxidase, cytochrome P450 enzymes,
Increased NRF2 activity as a result of decreased KEAP 1 levels increased expression of the …