Codeine exerts cardiorenal injury via upregulation of adenine deaminase/xanthine oxidase and caspase 3 signaling

RE Akhigbe, LO Ajayi, AF Ajayi - Life Sciences, 2021 - Elsevier
… Furthermore, cardiac lactate dehydrogenase activity increased significantly with likely
increase in myocardial lactate production. This is a pointer that the myocardial energy need …

Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes

T Okuyama, J Shirakawa, T Nakamura, T Murase… - Scientific reports, 2021 - nature.com
Increased XOR activity has been reported to be observed in patients with coronary artery
disease 7 , heart failure and obesity 8 , and also both in patients with type 1 and 2 diabetes …

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
… , heart failure and cardiac arrhythmias. Interactions between different oxidases or oxidase
… ; also known as NOS3), mitochondria and xanthine oxidase (XO) 1 . NOX is distinct from …

[HTML][HTML] Shortage of cellular ATP as a cause of diseases and strategies to enhance ATP

TA Johnson, HA Jinnah, N Kamatani - Frontiers in pharmacology, 2019 - frontiersin.org
… diabetes and improved prognosis for chronic heart failure patients. That … heart, skeletal
muscle, or brain after treatment with allopurinol or febuxostat to inhibit xanthine oxidoreductase

Isorhamnetin, the xanthine oxidase inhibitor from Sophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice

F Wang, X Zhao, X Su, D Song, F Zou, L Fang - Food & Function, 2021 - pubs.rsc.org
… Hyperuricemia is a metabolic condition closely linked to xanthine oxidase (XOD) function, …
chronic renal failure and acromegaly, residual Cr levels are usually significantly increased due …

Xanthine oxidase inhibitors: patent landscape and clinical development (2015–2020)

JV Singh, PMS Bedi, H Singh… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Xanthine oxidase (XO) is a molybdoflavoprotein that catalyzes the oxidative
hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction …

Hyperuricemia as a risk factor for atrial fibrillation due to soluble and crystalized uric acid

F Taufiq, P Li, J Miake, I Hisatome - Circulation Reports, 2019 - jstage.jst.go.jp
… stress derived from either xanthine oxidoreductase (XOR), … atrial action potential via enhanced
expression and activity of … -1, ASC or NLRP3 failed to enhance IL-1β secretion induced …

Allopurinol attenuates oxidative injury in rat hearts suffered ischemia/reperfusion via suppressing the xanthine oxidase/vascular peroxidase 1 pathway

YS Zhang, LQ Lu, YQ Jiang, NS Li, XJ Luo… - European Journal of …, 2021 - Elsevier
… There were reports that XO activity was upregulated in the hearts after I/R, and XO-… expression
and its activity were both upregulated in the I/R-treated rat hearts and H/R-treated cardiac

Increased serum uric acid level predicts poor prognosis in mildly severe chronic heart failure with reduced ejection fraction. An analysis from the MECKI score …

MF Piepoli, E Salvioni, U Corrà, F Doni… - European journal of …, 2020 - Elsevier
… A potential mechanism of SUA over-production in HF is the increased expression and
activity of xanthine oxidase with consequent elevated reactive oxygen species (ROS). The latter …

Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management

IP Pratomo, A Ariane, A Tedjo, R Heryanto… - Medical Journal of …, 2021 - mji.ui.ac.id
… This literature review investigates the action of xanthine oxidase as a component of the
biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the …