… NBS tests are dependent on decisions regarding cut-off values… the analyte panel during
routine expanded newborn screening… not sufficient funds for genetic screening by TREC testing. …

… our site, to account for different analytes and local protocols. … reporting uninformative cases
for PKU would have improved … of multiple cutoff values, and scales of abnormal results, this …

… the established cutoff values and thus were not technically screen … In this study, analyte ratios
were not included in the RF model … These results support our previous findings of improved …

… Newborn screening (NBS) laboratories in the United Kingdom adhere to common protocols
based on single analyte cutoff values (… Analyte was found not to be a significant factor and …

… span a range of analyte values near the cutoff. Our treatment … This overlap region is shown
as an expanded plot (Figure 1C… s t-test is statistically valid and has value, we do not discuss it …

… to 160 µmol/L, the number of recalls would be 12, with no … If we increased the cut-off value
for PKU detection from 120 µmol/L to … , the Phe values, as well as other analytes, can become …

… users to interpret results individualized for each patient and to better … Within this study,
analytes exhibited variation across two … of static and/or binned cutoff values is prone to excessive …

… half a million newborns screened each year. Babies that are … metabolic analytes measured
by MS/MS, 1 two analyte ratios … false-positive males was not significantly increased. Notably, …

… for Mucopolysaccharidosis type I (MPS I) has increased … interpretation can significantly
increase the specificity of … technology has pushed the boundaries of newborn screening to not …

… interpretation of an abnormal MS/MS result for a given analyte has been based on the
comparison to cutoff values (… too common to be resolved without improved strategies. An obvious …