Effects of L-Carnitine Supplementation on the Rate of Weight Gain and Biomarkers of Environmental Enteric Dysfunction in Children with Severe Acute Malnutrition: A …

J Alam, SM Fahim, MR Islam, MA Alam, MA Gazi… - The Journal of …, 2024 - Elsevier
carnitine inside the mitochondrion, and the liberated fatty acyl… Fecal EED biomarkers of
intestinal inflammation and altered gut … In our study, we found that the L-carnitine levels of our …

Role of L-Carnitine supplementation on rate of weight gain and biomarkers of Environmental Enteric Dysfunction in children with severe acute malnutrition: A protocol …

J Alam, MR Islam, SM Fahim, MA Gazi, T Ahmed - Plos one, 2022 - journals.plos.org
… , plays a critical role in the β-oxidation of fatty acids and energy production in the form of …
is associated with a secondary deficiency of carnitine [11]. Also, carnitine deficiency leading to …

Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction

A Bein, CW Fadel, B Swenor, W Cao… - Nature Biomedical …, 2022 - nature.com
fatty acids using fluorescently labelled dodecanoic acid, we found that exposure to nutritional
deficiency reduced fattyAltered intestinal inflammation is a key component of EED and our …

Nutritional deficiency recapitulates intestinal injury associated with environmental enteric dysfunction in patient-derived Organ Chips

A Bein, CW Fadel, B Swenor, W Cao, RK Powers… - medRxiv, 2021 - medrxiv.org
… exposure to nutritional deficiency reduced fatty acid uptake by … that similarly show impaired
fatty acid metabolism in children … Altered intestinal inflammation is a key component of EED …

Enterobacteriaceae Growth Promotion by Intestinal Acylcarnitines, a Biomarker of Dysbiosis in Inflammatory Bowel Disease

JMS Lemons, M Conrad, C Tanes, J Chen… - Cellular and Molecular …, 2024 - Elsevier
… increases fecal carnitine levels with enhanced intestinal colonization of the enteric pathogen
… IBD is associated with alterations in intestinal fatty acid metabolism. Rats treated rectally …

Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines

SA Smith, SA Ogawa, L Chau… - The Journal of …, 2021 - Am Soc Clin Investig
… the intestinal epithelium could also oxidize long-chain fatty … Medium- and long-chain fatty
acids are esterified to carnitine … To determine whether these alterations are also associated with …

[HTML][HTML] Disentangling microbial mediators of malnutrition: modeling environmental enteric dysfunction

LA Bartelt, DT Bolick, RL Guerrant - Cellular and Molecular …, 2019 - Elsevier
… protein deficiency (7% protein) is sufficient to alter intestinal … is associated with perturbations
in several host and intestinal … of secondary carnitine deficiency, blocked fatty acid oxidation, …

Dysbiosis of the intestinal microbiome as a component of pathophysiology in the inborn errors of metabolism

TO Kirby, J Ochoa-Reparaz, JB Roullet… - Molecular Genetics and …, 2021 - Elsevier
… excretion with the oral intake of l-carnitine in the disorders of fatty acid oxidation). While the
IEMs … causes alterations in host metabolite levels. These changes in metabolites can alter the …

[HTML][HTML] Altered metabolome and microbiome associated with compromised intestinal barrier induced hepatic lipid metabolic disorder in mice after subacute and …

W Lu, C Jiang, Y Chen, Z Lu, X Xu, L Zhu, H Xi… - Environment …, 2024 - Elsevier
… , the levels of linoleic acid, docosahexaenoic acid (DHA) and arachidonic acid, which are
enriched in the biosynthesis of unsaturated fatty … L-carnitine, an essential cofactor for fatty acid …

Carnitine

PR Borum - Present Knowledge in Nutrition, 2020 - Elsevier
… role of carnitine in beta-oxidation of long-chain fatty acids in … newborn screening has completely
changed the clinical care of … Carnitine deficiency from disorders of carnitine biosynthesis …