… of DNA methylation in embryonic, germline and somatic cell development. Finally, we
provide insights into DNA methylation gained from studying genetic … alkylation repair enzyme (…

… culturing [51], suggesting that, while DNMT1 is the major maintenance enzyme, DNMT3A
and DNMT3B are also required for stable and faithful maintenance of DNA methylation. …

… on the epigenetic regulation of DNA repair genes. We summarize the mechanisms underlying
CpG methylation and … Enzymatic DNA methylation occurs at the 5-C position of cytosine (5-…

… DNA demethylation, 5mC is diluted following several rounds of DNA replication due to the
absence of DNA methylation … active DNA demethylation, 5mC can be removed enzymatically …

… An enzyme- and bisulfite-free method for DNA methylation should overcome these
constraints and have many advantages such as speed, convenience, and low cost (Figure 4). …

… blood pressure regulation, … function and blood pressure regulation 48 . E2F transcription
factors regulate synthesis of dihydrofolate reductase (DHFR), the rate-limiting salvage enzyme …

… function by modifying the promoters of specific genes and … , reduced methylation of the
angiotensin I-converting enzyme-… experimentation based on epigenetic regulation in cell-, tissue-, …

… number of base-resolution methylation maps. Despite this, … role and interpretation of DNA
methylation patterns remain under investigation. Here, we review the field of DNA methylation …

… To overcome these issues, we developed EM-seq, an entirely enzyme-based method to
determine cytosine methylation status. This method relies on a trio of enzymes and their ability …

… marker and focused on promoter regions of genes for decades. … understanding of the roles
of DNA methylation to various genomic … DNA methylation patterns spawns a diversity of DNA …