Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation–Positive Non–Small Cell Lung Cancer
K Isomoto, K Haratani, H Hayashi, S Shimizu… - Clinical Cancer …, 2020 - AACR
… PFS is plotted according to PD-L1 expression level with a cutoff of 50% in tumor samples
obtained after EGFR-TKI treatment (D) or according to a change in PD-L1 expression status …
obtained after EGFR-TKI treatment (D) or according to a change in PD-L1 expression status …
Combination of selected MET and EGFR inhibitors decreases melanoma cells' invasive abilities
A Simiczyjew, K Pietraszek-Gremplewicz… - Frontiers in …, 2019 - frontiersin.org
… , inhibitors of EGFR (epidermal growth factor receptor), has a … However, there are cancer
cells resistant to drugs’ treatment … in response to treatment in biopsy-derived cells compared to …
cells resistant to drugs’ treatment … in response to treatment in biopsy-derived cells compared to …
Pyrimidine-based EGFR TK inhibitors in targeted cancer therapy
… and status of EGFR inhibitors in cancer therapy. In addition, we … The epidermal growth factor
receptor (EGFR) is a family of … better EGFR inhibition than urea containing derivatives. The …
receptor (EGFR) is a family of … better EGFR inhibition than urea containing derivatives. The …
Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance
… the highly effective antibodies targeting epidermal growth factor receptor (EGFR), have clinical
… to EGFR inhibitors. At the same time, the study also pointed out that the resistance to anti-…
… to EGFR inhibitors. At the same time, the study also pointed out that the resistance to anti-…
[HTML][HTML] SELECT: a phase II trial of adjuvant erlotinib in patients with resected epidermal growth factor receptor–mutant non–small-cell lung cancer
NA Pennell, JW Neal, JE Chaft, CG Azzoli… - Journal of Clinical …, 2019 - ncbi.nlm.nih.gov
… Targeted treatments have been shown to improve survival in … However, the majority of
patients derived benefit from re-… AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer…
patients derived benefit from re-… AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer…
Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance
MA Krook, JW Reeser, G Ernst, H Barker… - British Journal of …, 2021 - nature.com
… We describe the expanding landscape of anti-FGFR therapies that … , such as epidermal
growth factor receptor (EGFR) and … that FGFR inhibition with AZD4547 and EGFR inhibition with …
growth factor receptor (EGFR) and … that FGFR inhibition with AZD4547 and EGFR inhibition with …
HER2 positivity predicts unresponsiveness to EGFR‐targeted treatment in metastatic colorectal cancer
… to anti‐epidermal growth factor receptor (EGFR) treatment. … be obtained by a future independent
data set was 0.54. Referring to the subset of patients treated with anti‐EGFR therapy, the …
data set was 0.54. Referring to the subset of patients treated with anti‐EGFR therapy, the …
Immune resistance and EGFR antagonists in colorectal cancer
… Targeting the epidermal growth factor receptor (EGFR) either … (mCRC) has revolutionized
the treatment of CRC, but with … and EGFR inhibitors is able to decrease the in vitro growth of …
the treatment of CRC, but with … and EGFR inhibitors is able to decrease the in vitro growth of …
Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
Y Le, Y Gan, Y Fu, J Liu, W Li, X Zou… - … of enzyme inhibition …, 2020 - Taylor & Francis
… was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal
growth factor receptor tyrosine kinase (EGFR wt -TK) and three human cancer cell lines …
growth factor receptor tyrosine kinase (EGFR wt -TK) and three human cancer cell lines …
Afatinib-loaded immunoliposomes functionalized with cetuximab: A novel strategy targeting the epidermal growth factor receptor for treatment of non-small-cell lung …
X Lu, S Liu, M Han, X Yang, K Sun, H Wang… - International journal of …, 2019 - Elsevier
… chemotherapy was the only option to treat advanced NSCLC, but showed … epidermal growth
factor receptor (EGFR) overexpression in NSCLC, various EGFR tyrosine kinase inhibitors …
factor receptor (EGFR) overexpression in NSCLC, various EGFR tyrosine kinase inhibitors …