Human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer: current knowledge and future perspectives
… Lastly, we report prospects for the improvement of care for patients with HER2+ advanced …
-resistant derived xenograft, triple inhibition of EGFR, HER2, and human epidermal receptor 3 (…
-resistant derived xenograft, triple inhibition of EGFR, HER2, and human epidermal receptor 3 (…
Targeting epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) expressing bladder cancer using combination …
MR Siddiqui, R Railkar, T Sanford, DR Crooks… - Scientific reports, 2019 - nature.com
… with NIR light showed better growth inhibition over time compared to the other treatment arms
(n = … to a benzoprophyrin derivative (verteprofrin) are also non-specific, making selective …
(n = … to a benzoprophyrin derivative (verteprofrin) are also non-specific, making selective …
Complex crystal structures of EGFR with third-generation kinase inhibitors and simultaneously bound allosteric ligands
J Niggenaber, L Heyden, T Grabe… - ACS Medicinal …, 2020 - ACS Publications
… treatment of patients suffering from non-small cell lung cancer (NSCLC) harboring T790M-mutated
epidermal growth factor receptor (EGFR… the optimized allosteric EGFR inhibitor JBJ-04…
epidermal growth factor receptor (EGFR… the optimized allosteric EGFR inhibitor JBJ-04…
Molecular and clinical features of EGFR-TKI-associated lung injury
T Ohmori, T Yamaoka, K Ando, S Kusumoto… - International Journal of …, 2021 - mdpi.com
… The tyrosine kinase activity of epidermal growth factor receptors … of wild-type-EGFR inhibition.
Hepatic and pulmonary toxicity … Treatment with an EGFR-TKI is the current standard of care …
Hepatic and pulmonary toxicity … Treatment with an EGFR-TKI is the current standard of care …
MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer
Q Wang, S Yang, K Wang, SY Sun - Journal of hematology & oncology, 2019 - Springer
… The development of epidermal growth factor receptor (EGFR… to overcome resistance to EGFR
inhibitors by MET amplification [… Similarly, H1975-P1 cells resistant to AC0010 derived from …
inhibitors by MET amplification [… Similarly, H1975-P1 cells resistant to AC0010 derived from …
Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations
… EGFR (Epidermal Growth Factor Receptor) is highly expressed in 20–80% of NSCLC patients
[2]. EGFR belongs to the receptor … AZD9291 to treat patients with EGFR T790M mutations …
[2]. EGFR belongs to the receptor … AZD9291 to treat patients with EGFR T790M mutations …
Discovery of potent small molecule PROTACs targeting mutant EGFR
… Epidermal growth factor receptor (EGFR) is an important therapeutic target for the
treatment … Then, compounds P1 and P3 were obtained through acylation reaction of 8 with …
treatment … Then, compounds P1 and P3 were obtained through acylation reaction of 8 with …
Pharmacologic inhibition of epidermal growth factor receptor suppresses nonalcoholic fatty liver disease in a murine fast‐food diet model
… a role of EGFR in NAFLD and the potential of EGFR inhibition as a treatment strategy for …
(5) Similar results were obtained in this study, where the FFD-induced fatty liver phenotype …
(5) Similar results were obtained in this study, where the FFD-induced fatty liver phenotype …
Discovery and optimization of dibenzodiazepinones as allosteric mutant-selective EGFR inhibitors
DJH De Clercq, DE Heppner, C To, J Jang… - ACS medicinal …, 2019 - ACS Publications
… Activating mutations of the epidermal growth factor receptor (EGFR), eg, L858R and in-… cell
lung cancer and confer sensitivity to EGFR-targeted tyrosine kinase inhibitors (TKIs) such as …
lung cancer and confer sensitivity to EGFR-targeted tyrosine kinase inhibitors (TKIs) such as …
EGFR signaling pathway as therapeutic target in human cancers
… Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance of … led
us to understand EGFR and beyond, and highlight how they revolutionized cancer treatment by …
us to understand EGFR and beyond, and highlight how they revolutionized cancer treatment by …